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- PMID: 20477412
- UKPMCID: 20477412
- DOI: 10.2217/17520363.2.3.229
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Spectroscopy of human plasma for diagnosis of idiopathic Parkinson's disease.
Schipper, Hyman M; Kwok, C Shing; Rosendahl, Scott M; Bandilla, Dirk; Maes, Olivier; Melmed, Calvin; Rabinovitch, Daniel; Burns, David H
Biomarkers in medicine. 2008;2(3):229-38.
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Full-text held externally
- PMID: 20477412
- UKPMCID: 20477412
- DOI: 10.2217/17520363.2.3.229
Abstract
BACKGROUND: No established chemical biomarkers of idiopathic Parkinson's disease (PD) currently exist. Augmented oxidative stress (OS) has been implicated in both neural and peripheral PD tissues. METHODS: In this study, Raman scattering and near-infrared spectroscopy were used to detect and quantify oxidative substrate modifications in blood plasma samples from PD and normal elderly control (NEC) subjects. RESULTS: Hypothesis-driven preselection of OS-sensitive bandwidths distinguished PD from NEC subjects with approximately 75% sensitivity and specificity using both complementary spectroscopic techniques. CONCLUSION: Biospectroscopy of plasma may provide a rapid, minimally invasive and inexpensive chemical biomarker of idiopathic PD.