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- PMID: 25155250
- UKPMCID: 25155250
- DOI: 10.1016/j.ejca.2014.07.018
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Large contribution of human papillomavirus in vaginal neoplastic lesions: A worldwide study in 597 samples.
Alemany, L; Saunier, M; Tinoco, L; Quirós, B; Alvarado-Cabrero, I; Alejo, M; Joura, E A; Maldonado, P; Klaustermeier, J; Salmerón, J; Bergeron, C; Petry, K U; Guimerà , N; Clavero, O; Murillo, R; Clavel, C; Wain, V; Geraets, D T; Jach, R; Cross, P; Carrilho, C; Molina, C; Shin, H R; Mandys, V; Nowakowski, A M; Vidal, A; Lombardi, L; Kitchener, H; Sica, A R; Magaña-León, C; Pawlita, M; Quint, W; Bravo, I G; Muñoz, N; de Sanjosé, S; Bosch, F X;
European journal of cancer (Oxford, England : 1990). 2014;50(16):2846-54.
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Full-text held externally
- PMID: 25155250
- UKPMCID: 25155250
- DOI: 10.1016/j.ejca.2014.07.018
Abstract
AIM: This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a large series of vaginal intraepithelial neoplasia (VAIN) grades 2/3 and vaginal cancer worldwide. METHODS: We analysed 189 VAIN 2/3 and 408 invasive vaginal cancer cases collected from 31 countries from 1986 to 2011. After histopathological evaluation of sectioned formalin-fixed paraffin-embedded samples, HPV DNA detection and typing was performed using the SPF-10/DNA enzyme immunoassay (DEIA)/LiPA25 system (version 1). A subset of 146 vaginal cancers was tested for p16(INK4a) expression, a cellular surrogate marker for HPV transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance. RESULTS: HPV DNA was detected in 74% (95% confidence interval (CI): 70-78%) of invasive cancers and in 96% (95% CI: 92-98%) of VAIN 2/3. Among cancers, the highest detection rates were observed in warty-basaloid subtype of squamous cell carcinomas, and in younger ages. Concerning the type-specific distribution, HPV16 was the most frequently type detected in both precancerous and cancerous lesions (59%). p16(INK4a) overexpression was found in 87% of HPV DNA positive vaginal cancer cases. CONCLUSIONS: HPV was identified in a large proportion of invasive vaginal cancers and in almost all VAIN 2/3. HPV16 was the most common type detected. A large impact in the reduction of the burden of vaginal neoplastic lesions is expected among vaccinated cohorts.
Bibliographic metadata
- Alemany, L
- Saunier, M
- Tinoco, L
- Quirós, B
- Alvarado-Cabrero, I
- Alejo, M
- Joura, E A
- Maldonado, P
- Klaustermeier, J
- Salmerón, J
- Bergeron, C
- Petry, K U
- Guimerà , N
- Clavero, O
- Murillo, R
- Clavel, C
- Wain, V
- Geraets, D T
- Jach, R
- Cross, P
- Carrilho, C
- Molina, C
- Shin, H R
- Mandys, V
- Nowakowski, A M
- Vidal, A
- Lombardi, L
- Kitchener, H
- Sica, A R
- Magaña-León, C
- Pawlita, M
- Quint, W
- Bravo, I G
- Muñoz, N
- de Sanjosé, S
- Bosch, F X