Related resources
Full-text held externally
- PMID: 22293568
- UKPMCID: 22293568
- DOI: 10.1038/nrd3628
Search for item elsewhere
University researcher(s)
Academic department(s)
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy.
Millan, Mark J; Agid, Yves; Brüne, Martin; Bullmore, Edward T; Carter, Cameron S; Clayton, Nicola S; Connor, Richard; Davis, Sabrina; Deakin, Bill; DeRubeis, Robert J; Dubois, Bruno; Geyer, Mark A; Goodwin, Guy M; Gorwood, Philip; Jay, Thérèse M; Joëls, Marian; Mansuy, Isabelle M; Meyer-Lindenberg, Andreas; Murphy, Declan; Rolls, Edmund; Saletu, Bernd; Spedding, Michael; Sweeney, John; Whittington, Miles; Young, Larry J
Nature reviews. Drug discovery. 2012;11(2):141-68.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Full-text is available externally using the following links:
Full-text held externally
- PMID: 22293568
- UKPMCID: 22293568
- DOI: 10.1038/nrd3628
Abstract
Studies of psychiatric disorders have traditionally focused on emotional symptoms such as depression, anxiety and hallucinations. However, poorly controlled cognitive deficits are equally prominent and severely compromise quality of life, including social and professional integration. Consequently, intensive efforts are being made to characterize the cellular and cerebral circuits underpinning cognitive function, define the nature and causes of cognitive impairment in psychiatric disorders and identify more effective treatments. Successful development will depend on rigorous validation in animal models as well as in patients, including measures of real-world cognitive functioning. This article critically discusses these issues, highlighting the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders.
Bibliographic metadata
- Millan, Mark J
- Agid, Yves
- Brüne, Martin
- Bullmore, Edward T
- Carter, Cameron S
- Clayton, Nicola S
- Connor, Richard
- Davis, Sabrina
- Deakin, Bill
- DeRubeis, Robert J
- Dubois, Bruno
- Geyer, Mark A
- Goodwin, Guy M
- Gorwood, Philip
- Jay, Thérèse M
- Joëls, Marian
- Mansuy, Isabelle M
- Meyer-Lindenberg, Andreas
- Murphy, Declan
- Rolls, Edmund
- Saletu, Bernd
- Spedding, Michael
- Sweeney, John
- Whittington, Miles
- Young, Larry J