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- PMID: 25772593
- UKPMCID: 25772593
- DOI: 10.1016/j.jaci.2014.12.1949
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Hazelnut allergy across Europe dissected molecularly: AÂ EuroPrevall outpatient clinic survey.
Datema, Mareen R; Zuidmeer-Jongejan, Laurian; Asero, Riccardo; Barreales, Laura; Belohlavkova, Simona; de Blay, Frédéric; Bures, Peter; Clausen, Michael; Dubakiene, Ruta; Gislason, David; Jedrzejczak-Czechowicz, Monika; Kowalski, Marek L; Knulst, André C; Kralimarkova, Tanya; Le, Thuy-My; Lovegrove, Alison; Marsh, Justin; Papadopoulos, Nikolaos G; Popov, Todor; Del Prado, Náyade; Purohit, Ashok; Reese, Gerald; Reig, Isabel; Seneviratne, Suranjith L; Sinaniotis, Athanasios; Versteeg, Serge A; Vieths, Stefan; Zwinderman, Aeilko H; Mills, Clare; Lidholm, Jonas; Hoffmann-Sommergruber, Karin; Fernández-Rivas, Montserrat; Ballmer-Weber, Barbara; van Ree, Ronald
The Journal of allergy and clinical immunology. 2015;.
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Full-text held externally
- PMID: 25772593
- UKPMCID: 25772593
- DOI: 10.1016/j.jaci.2014.12.1949
Abstract
BACKGROUND: Hazelnut allergy is birch pollen-driven in Northern/Western Europe and lipid transfer protein-driven in Spain and Italy. Little is known about other regions and other allergens. OBJECTIVE: Establishing a molecular map of hazelnut allergy across Europe. METHODS: In 12 European cities, subjects reporting reactions to hazelnut (n = 731) were evaluated and sensitization to 24 foods, 12 respiratory allergen sources, and latex was tested by using skin prick test and ImmunoCAP. A subset (124 of 731) underwent a double-blind placebo-controlled food challenge to hazelnut. Sera of 423 of 731 subjects were analyzed for IgE against 7 hazelnut allergens and cross-reactive carbohydrate determinants by ImmunoCAP. RESULTS: Hazelnut allergy was confirmed in 70% of those undergoing double-blind placebo-controlled food challenges. Birch pollen-driven hazelnut sensitization (Cor a 1) dominated in most cities, except in Reykjavik, Sofia, Athens, and Madrid, where reporting of hazelnut allergy was less frequent anyhow. In Athens, IgE against Cor a 8 dominated and strongly correlated with IgE against walnut, peach, and apple and against Chenopodium, plane tree, and mugwort pollen. Sensitization to seed storage proteins was observed in less than 10%, mainly in children, and correlated with IgE to nuts, seeds, and legumes. IgE to Cor a 12, observed in all cities (10% to 25%), correlated with IgE to nuts, seeds, and pollen. CONCLUSIONS: In adulthood, the importance of hazelnut sensitization to storage proteins, oleosin (Cor a 12), and Cor a 8 is diluted by the increased role of birch pollen cross-reactivity with Cor a 1. Cor a 8 sensitization in the Mediterranean is probably driven by diet in combination with pollen exposure. Hazelnut oleosin sensitization is prevalent across Europe; however, the clinical relevance remains to be established.
Bibliographic metadata
- Datema, Mareen R
- Zuidmeer-Jongejan, Laurian
- Asero, Riccardo
- Barreales, Laura
- Belohlavkova, Simona
- de Blay, Frédéric
- Bures, Peter
- Clausen, Michael
- Dubakiene, Ruta
- Gislason, David
- Jedrzejczak-Czechowicz, Monika
- Kowalski, Marek L
- Knulst, André C
- Kralimarkova, Tanya
- Le, Thuy-My
- Lovegrove, Alison
- Marsh, Justin
- Papadopoulos, Nikolaos G
- Popov, Todor
- Del Prado, Náyade
- Purohit, Ashok
- Reese, Gerald
- Reig, Isabel
- Seneviratne, Suranjith L
- Sinaniotis, Athanasios
- Versteeg, Serge A
- Vieths, Stefan
- Zwinderman, Aeilko H
- Mills, Clare
- Lidholm, Jonas
- Hoffmann-Sommergruber, Karin
- Fernández-Rivas, Montserrat
- Ballmer-Weber, Barbara
- van Ree, Ronald