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- PMID: 25830527
- UKPMCID: 25830527
- DOI: 10.1164/rccm.201501-0044ST
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An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease.
Celli, Bartolome R; Decramer, Marc; Wedzicha, Jadwiga A; Wilson, Kevin C; AgustÃ, Alvar; Criner, Gerard J; MacNee, William; Make, Barry J; Rennard, Stephen I; Stockley, Robert A; Vogelmeier, Claus; Anzueto, Antonio; Au, David H; Barnes, Peter J; Burgel, Pierre-Regis; Calverley, Peter M; Casanova, Ciro; Clini, Enrico M; Cooper, Christopher B; Coxson, Harvey O; Dusser, Daniel J; Fabbri, Leonardo M; Fahy, Bonnie; Ferguson, Gary T; Fisher, Andrew; Fletcher, Monica J; Hayot, Maurice; Hurst, John R; Jones, Paul W; Mahler, Donald A; Maltais, François; Mannino, David M; Martinez, Fernando J; Miravitlles, Marc; Meek, Paula M; Papi, Alberto; Rabe, Klaus F; Roche, Nicolas; Sciurba, Frank C; Sethi, Sanjay; Siafakas, Nikos; Sin, Don D; Soriano, Joan B; Stoller, James K; Tashkin, Donald P; Troosters, Thierry; Verleden, Geert M; Verschakelen, Johny; Vestbo, Jorgen; Walsh, John W; Washko, George R; Wise, Robert A; Wouters, Emiel F M; ZuWallack, Richard L;
American journal of respiratory and critical care medicine. 2015;191(7):e4-e27.
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Full-text held externally
- PMID: 25830527
- UKPMCID: 25830527
- DOI: 10.1164/rccm.201501-0044ST
Abstract
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management. METHODS: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified. RESULTS: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus. CONCLUSIONS: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes.
Bibliographic metadata
- Celli, Bartolome R
- Decramer, Marc
- Wedzicha, Jadwiga A
- Wilson, Kevin C
- AgustÃ, Alvar
- Criner, Gerard J
- MacNee, William
- Make, Barry J
- Rennard, Stephen I
- Stockley, Robert A
- Vogelmeier, Claus
- Anzueto, Antonio
- Au, David H
- Barnes, Peter J
- Burgel, Pierre-Regis
- Calverley, Peter M
- Casanova, Ciro
- Clini, Enrico M
- Cooper, Christopher B
- Coxson, Harvey O
- Dusser, Daniel J
- Fabbri, Leonardo M
- Fahy, Bonnie
- Ferguson, Gary T
- Fisher, Andrew
- Fletcher, Monica J
- Hayot, Maurice
- Hurst, John R
- Jones, Paul W
- Mahler, Donald A
- Maltais, François
- Mannino, David M
- Martinez, Fernando J
- Miravitlles, Marc
- Meek, Paula M
- Papi, Alberto
- Rabe, Klaus F
- Roche, Nicolas
- Sciurba, Frank C
- Sethi, Sanjay
- Siafakas, Nikos
- Sin, Don D
- Soriano, Joan B
- Stoller, James K
- Tashkin, Donald P
- Troosters, Thierry
- Verleden, Geert M
- Verschakelen, Johny
- Vestbo, Jorgen
- Walsh, John W
- Washko, George R
- Wise, Robert A
- Wouters, Emiel F M
- ZuWallack, Richard L
- Celli, Bartolome R
- Decramer, Marc
- Wedzicha, Jadwiga A
- Wilson, Kevin C
- Agust, Alvar
- Criner, Gerard J
- MacNee, William
- Make, Barry J
- Rennard, Stephen I
- Stockley, Robert A
- Vogelmeier, Claus
- Anzueto, Antonio
- Au, David H
- Barnes, Peter J
- Burgel, Pierre-Regis
- Calverley, Peter M
- Casanova, Ciro
- Clini, Enrico M
- Cooper, Christopher B
- Coxson, Harvey O
- Dusser, Daniel J
- Fabbri, Leonardo M
- Fahy, Bonnie
- Ferguson, Gary T
- Fisher, Andrew
- Fletcher, Monica J
- Hayot, Maurice
- Hurst, John R
- Jones, Paul W
- Mahler, Donald A
- Maltais, François
- Mannino, David M
- Martinez, Fernando J
- Miravitlles, Marc
- Meek, Paula M
- Papi, Alberto
- Rabe, Klaus F
- Roche, Nicolas
- Sciurba, Frank C
- Sethi, Sanjay
- Siafakas, Nikos
- Sin, Don D
- Soriano, Joan B
- Stoller, James K
- Tashkin, Donald P
- Troosters, Thierry
- Verleden, Geert M
- Verschakelen, Johny
- Vestbo, Jorgen
- Walsh, John W
- Washko, George R
- Wise, Robert A
- Wouters, Emiel F M
- Zuwallack, Richard L