Related resources
Search for item elsewhere
University researcher(s)
Facilitation of displacements at the 6-position of purines by the use of 1,4-diazabicyclo[2.2.2]octane as leaving group
Lembicz, Nicola K; Grant, Sharon; Clegg, William; Griffin, Roger J; Heath, Sarah L; Golding, Bernard T
J. Chem. Soc., Perkin Trans. 1. 1997;(3):185-186.
Access to files
Full-text and supplementary files are not available from Manchester eScholar. Use our list of Related resources to find this item elsewhere. Alternatively, request a copy from the Library's Document supply service.
Abstract
Reactions of 6-chloropurines with 1,4-diazabicyclo[2.2.2]octane (DABCO) give the corresponding 'DABCO-purines' I (X = NH2, H, Cl, Y = H; X = NH2, Y = β-D-ribofuranosyl), which undergo facile displacement reactions with alkoxides in DMSO to afford 6-oxy-substituted purines II (R = Me, allyl, CH2Ph, cyclohexylmethyl, 2-thienylmethyl, etc.). [on SciFinder(R)]
Bibliographic metadata
- CAPLUS AN 1997:136347(Journal)