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Refractory asthma - beyond step 5, the role of new and emerging adjuvant therapies.

Kane, Binita; Fowler, Stephen J; Niven, Rob

Chronic respiratory disease. 2015;12(1):69-77.

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Abstract

A small percentage of asthmatics have 'severe refractory asthma', where there is suboptimal response to currently available therapies. A number of novel therapies targeting key biological targets are becoming available. Asthma is a heterogeneous disease, and systematic evaluation of patients is important to target therapies to the underlying inflammatory subtype and clinical features. This review article outlines new and emerging treatments for severe asthma, including monoclonal antibodies targeting eosinophilic disease, anti-neutrophil strategies, novel bronchodilators and bronchial thermoplasty. We highlight the importance of individualized investigation, treatment and management of severe asthmatics.

Keyword(s)

Refractory; asthma; novel; therapy

Bibliographic metadata

Type of resource:

text

Content type:

Journal article

Publication type:

Review article

Author(s):

Published date:

2015-02

Article title:

Refractory asthma - beyond step 5, the role of new and emerging adjuvant therapies.

Journal title:

Chronic respiratory disease

Abbreviated journal title:

Chron Respir Dis

ISSN:

1479-9731

Place of publication:

England

Volume:

Issue:

Pagination:

69-77

Digital Object Identifier:

10.1177/1479972314562210

Pubmed Identifier:

25492977

Pii Identifier:

1479972314562210

Access state:

Active

Institutional metadata

University researcher(s):

Fowler, Stephen

Academic department(s):

Record metadata

Manchester eScholar ID:

uk-ac-man-scw:288758

Created by:

Fowler, Stephen

Created:

15th December, 2015, 08:59:24

Last modified by:

Fowler, Stephen

Last modified:

15th December, 2015, 08:59:24