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- PMID: 11237015
- UKPMCID: 11237015
- DOI: 10.1038/35057165
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The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.
Bentley, D R; Deloukas, P; Dunham, A; French, L; Gregory, S G; Humphray, S J; Mungall, A J; Ross, M T; Carter, N P; Dunham, I; Scott, C E; Ashcroft, K J; Atkinson, A L; Aubin, K; Beare, D M; Bethel, G; Brady, N; Brook, J C; Burford, D C; Burrill, W D; Burrows, C; Butler, A P; Carder, C; Catanese, J J; Clee, C M; Clegg, S M; Cobley, V; Coffey, A J; Cole, C G; Collins, J E; Conquer, J S; Cooper, R A; Culley, K M; Dawson, E; Dearden, F L; Durbin, R M; de Jong, P J; Dhami, P D; Earthrowl, M E; Edwards, C A; Evans, R S; Gillson, C J; Ghori, J; Green, L; Gwilliam, R; Halls, K S; Hammond, S; Harper, G L; Heathcott, R W; Holden, J L; Holloway, E; Hopkins, B L; Howard, P J; Howell, G R; Huckle, E J; Hughes, J; Hunt, P J; Hunt, S E; Izmajlowicz, M; Jones, C A; Joseph, S S; Laird, G; Langford, C F; Lehvaslaiho, M H; Leversha, M A; McCann, O T; McDonald, L M; McDowall, J; Maslen, G L; Mistry, D; Moschonas, N K; Neocleous, V; Pearson, D M; Phillips, K J; Porter, K M; Prathalingam, S R; Ramsey, Y H; Ranby, S A; Rice, C M; Rogers, J; Rogers, L J; Sarafidou, T; Scott, D J; Sharp, G J; Shaw-Smith, C J; Smink, L J; Soderlund, C; Sotheran, E C; Steingruber, H E; Sulston, J E; Taylor, A; Taylor, R G; Thorpe, A A; Tinsley, E; Warry, G L; Whittaker, A; Whittaker, P; Williams, S H; Wilmer, T E; Wooster, R; Wright, C L
Nature. 2001;409(6822):942-3.
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Full-text held externally
- PMID: 11237015
- UKPMCID: 11237015
- DOI: 10.1038/35057165
Abstract
We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and problem-solving was simplified by containment within local regions. The maps currently represent more than 94% of the euchromatic (gene-containing) regions of these chromosomes in 176 contigs, and contain 96% of the chromosome-specific markers in the human gene map. By measuring the remaining gaps, we can assess chromosome length and coverage in sequenced clones.
Bibliographic metadata
- Bentley, D R
- Deloukas, P
- Dunham, A
- French, L
- Gregory, S G
- Humphray, S J
- Mungall, A J
- Ross, M T
- Carter, N P
- Dunham, I
- Scott, C E
- Ashcroft, K J
- Atkinson, A L
- Aubin, K
- Beare, D M
- Bethel, G
- Brady, N
- Brook, J C
- Burford, D C
- Burrill, W D
- Burrows, C
- Butler, A P
- Carder, C
- Catanese, J J
- Clee, C M
- Clegg, S M
- Cobley, V
- Coffey, A J
- Cole, C G
- Collins, J E
- Conquer, J S
- Cooper, R A
- Culley, K M
- Dawson, E
- Dearden, F L
- Durbin, R M
- de Jong, P J
- Dhami, P D
- Earthrowl, M E
- Edwards, C A
- Evans, R S
- Gillson, C J
- Ghori, J
- Green, L
- Gwilliam, R
- Halls, K S
- Hammond, S
- Harper, G L
- Heathcott, R W
- Holden, J L
- Holloway, E
- Hopkins, B L
- Howard, P J
- Howell, G R
- Huckle, E J
- Hughes, J
- Hunt, P J
- Hunt, S E
- Izmajlowicz, M
- Jones, C A
- Joseph, S S
- Laird, G
- Langford, C F
- Lehvaslaiho, M H
- Leversha, M A
- McCann, O T
- McDonald, L M
- McDowall, J
- Maslen, G L
- Mistry, D
- Moschonas, N K
- Neocleous, V
- Pearson, D M
- Phillips, K J
- Porter, K M
- Prathalingam, S R
- Ramsey, Y H
- Ranby, S A
- Rice, C M
- Rogers, J
- Rogers, L J
- Sarafidou, T
- Scott, D J
- Sharp, G J
- Shaw-Smith, C J
- Smink, L J
- Soderlund, C
- Sotheran, E C
- Steingruber, H E
- Sulston, J E
- Taylor, A
- Taylor, R G
- Thorpe, A A
- Tinsley, E
- Warry, G L
- Whittaker, A
- Whittaker, P
- Williams, S H
- Wilmer, T E
- Wooster, R
- Wright, C L