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- PMID: 9634230
- UKPMCID: 9634230
- DOI: 10.1038/31159
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Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Cole, S T; Brosch, R; Parkhill, J; Garnier, T; Churcher, C; Harris, D; Gordon, S V; Eiglmeier, K; Gas, S; Barry, C E; Tekaia, F; Badcock, K; Basham, D; Brown, D; Chillingworth, T; Connor, R; Davies, R; Devlin, K; Feltwell, T; Gentles, S; Hamlin, N; Holroyd, S; Hornsby, T; Jagels, K; Krogh, A; McLean, J; Moule, S; Murphy, L; Oliver, K; Osborne, J; Quail, M A; Rajandream, M A; Rogers, J; Rutter, S; Seeger, K; Skelton, J; Squares, R; Squares, S; Sulston, J E; Taylor, K; Whitehead, S; Barrell, B G
Nature. 1998;393(6685):537-44.
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Full-text held externally
- PMID: 9634230
- UKPMCID: 9634230
- DOI: 10.1038/31159
Abstract
Countless millions of people have died from tuberculosis, a chronic infectious disease caused by the tubercle bacillus. The complete genome sequence of the best-characterized strain of Mycobacterium tuberculosis, H37Rv, has been determined and analysed in order to improve our understanding of the biology of this slow-growing pathogen and to help the conception of new prophylactic and therapeutic interventions. The genome comprises 4,411,529 base pairs, contains around 4,000 genes, and has a very high guanine + cytosine content that is reflected in the biased amino-acid content of the proteins. M. tuberculosis differs radically from other bacteria in that a very large portion of its coding capacity is devoted to the production of enzymes involved in lipogenesis and lipolysis, and to two new families of glycine-rich proteins with a repetitive structure that may represent a source of antigenic variation.
Bibliographic metadata
- Cole, S T
- Brosch, R
- Parkhill, J
- Garnier, T
- Churcher, C
- Harris, D
- Gordon, S V
- Eiglmeier, K
- Gas, S
- Barry, C E
- Tekaia, F
- Badcock, K
- Basham, D
- Brown, D
- Chillingworth, T
- Connor, R
- Davies, R
- Devlin, K
- Feltwell, T
- Gentles, S
- Hamlin, N
- Holroyd, S
- Hornsby, T
- Jagels, K
- Krogh, A
- McLean, J
- Moule, S
- Murphy, L
- Oliver, K
- Osborne, J
- Quail, M A
- Rajandream, M A
- Rogers, J
- Rutter, S
- Seeger, K
- Skelton, J
- Squares, R
- Squares, S
- Sulston, J E
- Taylor, K
- Whitehead, S
- Barrell, B G