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- DOI: 10.1002/acr.20166
- PMID: 20191572
- UKPMCID: 20191572
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The independent effect of pain in one versus two knees on the presence of low physical function: The MOST study.
White, Daniel K; Zhang, Yuqing; Felson, David T; Niu, Jingbo; Keysor, Julie J; Nevitt, Michael C; Lewis, Cora E; Torner, James C; Neogi, Tuhina
Arthritis care & research. 2010;62(7):938-943.
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Full-text held externally
- DOI: 10.1002/acr.20166
- PMID: 20191572
- UKPMCID: 20191572
Abstract
While knee pain severity is thought to greatly impact function, the additional contribution of pain in one versus two knees is not known. We examined the relation between unilateral versus bilateral pain with low physical functioning at baseline and at 30 months while accounting for knee pain severity.The Multicenter Osteoarthritis Study (MOST) is a cohort study of people who have or are at high risk for knee OA. We defined low physical function as WOMAC PF scores >/=28/68, consistent with poor functional outcome. Incidence and improvement from low physical function were defined as scores that declined below and improved above this threshold at 30 months. We examined the association between pain in one or two knees with low physical function with risk ratios adjusting for known confounders.Of the 2069 subjects (Age 63 +/- 8 yrs, BMI 31 +/- 6 kg/m(2), female 63%), the prevalence of low physical functioning was 50% lower among persons with unilateral pain compared with those with bilateral pain [adj PR 0.5 (95% CI 0.4-0.7)]. Of those without low physical functioning at baseline, the risk of incidence at 30 months was 30% less for unilateral pain compared with bilateral pain [adj RR 0.7 (95% CI 0.5-1.0)]. Of those with low physical functioning at baseline, improvement was 1.7 times more likely for those with unilateral pain compared with bilateral pain [adj RR 1.7 (95%CI 1.3-2.2)].