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- PMID: 20628396
- UKPMCID: 20628396
- DOI: 10.1038/sj.bjc.6605747
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Multi-site study of HPV type-specific prevalence in women with cervical cancer, intraepithelial neoplasia and normal cytology, in England.
Howell-Jones, R; Bailey, A; Beddows, S; Sargent, A; de Silva, N; Wilson, G; Anton, J; Nichols, T; Soldan, K; Kitchener, H;
British journal of cancer. 2010;103(2):209-16.
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Full-text held externally
- PMID: 20628396
- UKPMCID: 20628396
- DOI: 10.1038/sj.bjc.6605747
Abstract
BACKGROUND: Knowledge of the prevalence of type-specific human papillomavirus (HPV) infections is necessary to predict the expected, and to monitor the actual, impact of HPV immunisation and to design effective screening strategies for vaccinated populations. METHODS: Residual specimens of cervical cytology (N=4719), CIN3/CGIN and cervical cancer biopsies (N=1515) were obtained from sites throughout England, anonymised and tested for HPV DNA using the Linear Array typing system (Roche). RESULTS: The prevalence of HPV 16 and/or 18 (with or without another high-risk (HR) type) was 76% in squamous cell carcinomas, 82% in adeno/adenosquamous carcinomas and 63% and 91% in CIN3 and CGIN, respectively. Of all HR HPV-infected women undergoing cytology, non-vaccine HPV types only were found in over 60% of those with mild dyskaryosis or below, and in <20% of those with cancer. In women of all ages undergoing screening, HR HPV prevalence was 16% and HPV 16 and/or 18 prevalence was 5%. CONCLUSION: Pre-immunisation, high-grade cervical disease in England was predominantly associated with HPV 16 and/or 18, which promises a high impact from HPV immunisation in due course. Second-generation vaccines and screening strategies need to consider the best ways to detect and prevent disease due to the remaining HR HPV types.
Bibliographic metadata
- Bailey, Andrew
- Kitchener, Henry
- Sargent, Alex
- Beddows, Simon
- Lowndes, Catherine
- Parry, John
- Soldan, Kate
- Bullock, Phil
- Cross, Paul
- Jones, Martin
- Johnson, Trudy
- Lonsdale, Ray
- Wood, Richard
- Taylor, Carol
- Patnick, Julietta
- Singh, Naveena
- Smith, John
- Waddell, Christine
- Ganesan, Raji
- Bentley, Linda
- Adams, Jane
- Young, Martin
- McGloin, John