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- DOI: 10.1016/j.joca.2010.10.027
- PMID: 21059398
- UKPMCID: 21059398
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Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA Consortium
Kerkhof, Hanneke J M; Meulenbelt, Ingrid; Akune, Toru; Arden, Nigel K; Aromaa, Arpo; Bierma-Zeinstra, Sita M A; Carr, Andrew; Cooper, Cyrus; Dai, Jin; Doherty, Michael; Doherty, Sally A; Felson, David; Gonzalez, Antonio; Gordon, Andrew; Harilainen, Arsi; Hart, Deborah J; Hauksson, Valdimar B; Heliovaara, Markku; Hofman, Albert; Ikegawa, Shiro; Ingvarsson, Thorvaldur; Jiang, Qing; Jonsson, Helgi; Jonsdottir, Ingileif; Kawaguchi, Hiroshi; Kloppenburg, Margreet; Kujala, Urho M; Lane, Nancy E; Leino-Arjas, Paivi; Lohmander, L Stefan; Luyten, Frank P; Malizos, Konstantinos N; Nakajima, Masahiro; Nevitt, Michael C; Pols, Huibert A P; Rivadeneira, Fernando; Shi, Dongquan; Slagboom, Eline; Spector, Tim D; Stefansson, Kari; Sudo, Akihiro; Tamm, Agu; Tamm, Ann E; Tsezou, Aspasia; Uchida, Atsumasa; Uitterlinden, André G; Wilkinson, Jeremy Mark; Yoshimura, Noriko; Valdes, Ana M; van Meurs, Joyce B J
Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 2011;19(3):254-264.
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Full-text held externally
- DOI: 10.1016/j.joca.2010.10.027
- PMID: 21059398
- UKPMCID: 21059398
Abstract
OBJECTIVE: To address the need for standardization of osteoarthritis (OA) phenotypes by examining the effect of heterogeneity among symptomatic (SOA) and radiographic osteoarthritis (ROA) phenotypes. METHODS: Descriptions of OA phenotypes of the 28 studies involved in the TREAT-OA consortium were collected. We investigated whether different OA definitions result in different association results by creating various hip OA definitions in one large population based cohort (the Rotterdam Study-I) and testing those for association with gender, age and BMI using one-way ANOVA. For radiographic OA, we standardized the hip, knee and hand ROA definitions and calculated prevalence's of ROA before and after standardization in 9 cohort studies. This procedure could only be performed in cohort studies and standardization of SOA definitions was not feasible at this moment. RESULTS: In this consortium, all studies with symptomatic OA phenotypes (knee, hip and hand) used a different definition and/or assessment of OA status. For knee, hip and hand radiographic OA 5, 4 and 7 different definitions were used, respectively. Different hip OA definitions do lead to different association results. For example, we showed in the Rotterdam Study-I that hip OA defined as "at least definite JSN and one definite osteophyte" was not associated with gender (p=0.22), but defined as "at least one definite osteophyte" was significantly associated with gender (p=3x10(-9)). Therefore, a standardization process was undertaken for radiographic OA definitions. Before standardization a wide range of ROA prevalence's was observed in the 9 cohorts studied. After standardization the range in prevalence of knee and hip ROA was small. CONCLUSION: Phenotype definitions influence the prevalence of OA and association with clinical variables. ROA phenotypes within the TREAT-OA consortium were standardized to reduce heterogeneity and improve power in future genetics studies.
Bibliographic metadata
- Kerkhof, Hanneke J M
- Meulenbelt, Ingrid
- Akune, Toru
- Arden, Nigel K
- Aromaa, Arpo
- Bierma-Zeinstra, Sita M A
- Carr, Andrew
- Cooper, Cyrus
- Dai, Jin
- Doherty, Michael
- Doherty, Sally A
- Felson, David
- Gonzalez, Antonio
- Gordon, Andrew
- Harilainen, Arsi
- Hart, Deborah J
- Hauksson, Valdimar B
- Heliovaara, Markku
- Hofman, Albert
- Ikegawa, Shiro
- Ingvarsson, Thorvaldur
- Jiang, Qing
- Jonsson, Helgi
- Jonsdottir, Ingileif
- Kawaguchi, Hiroshi
- Kloppenburg, Margreet
- Kujala, Urho M
- Lane, Nancy E
- Leino-Arjas, Paivi
- Lohmander, L Stefan
- Luyten, Frank P
- Malizos, Konstantinos N
- Nakajima, Masahiro
- Nevitt, Michael C
- Pols, Huibert A P
- Rivadeneira, Fernando
- Shi, Dongquan
- Slagboom, Eline
- Spector, Tim D
- Stefansson, Kari
- Sudo, Akihiro
- Tamm, Agu
- Tamm, Ann E
- Tsezou, Aspasia
- Uchida, Atsumasa
- Uitterlinden, André G
- Wilkinson, Jeremy Mark
- Yoshimura, Noriko
- Valdes, Ana M
- van Meurs, Joyce B J