Kinetically selective binding of single stranded RNA over DNA by a pyrrolidine-amide oligonucleotide mimic (POM).

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Abstract

Replacing the sugar-phosphodiester backbone of nucleic acids with a pyrrolidine-amide backbone results in an oligonucleotide mimic (POM) which binds with high affinity and specificity to complementary DNA and RNA. Unlike other modified oligonucleotides, POM binds much more rapidly to single stranded RNA than DNA.

Keyword(s)

Molecular association Nucleic acid hybridization (prepn. and RNA and DNA binding properties of a novel pyrrolidine-amide oligonucleotide) RNA Role: PRP (Properties) (prepn. and RNA and DNA binding properties of a novel pyrrolidine-amide oligonucleotide) DNA Role: PRP (Properties) (single-stranded prepn. and RNA and DNA binding properties of a novel pyrrolidine-amide oligonucleotide)

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