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An examination of the drug transport properties of liquid crystal embedded membranes.
Watson, Samantha J.; Gleeson, Helen F.; D'Emanuele, Antony
Molecular Crystals and Liquid Crystals Science and Technology, Section A: Molecular Crystals and Liquid Crystals. 2001;367:435-443.
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Abstract
Cellulose nitrate membranes were embedded with two different com. available liq. crystals and the transport of a model drug through the membranes was examd. spectrophotometrically. It was found that upon changing the temp. of the system, membranes without liq. crystal showed no temp. dependent drug transport properties. Membranes embedded with liq. crystal however, showed a distinct temp. variation in the drug release. It was found that the rate of drug transport was dependent on the amt. of liq. crystal deposited on the membrane and by cycling the temp. of the system, pulsatile drug release could be achieved. [on SciFinder (R)]
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