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- DOI: 10.1002/mrm.21066
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Experimentally-derived functional form for a population-averaged high temporal resolution arterial input function for dynamic contrast-enhanced MRI
Parker, GJM, Roberts, C, Macdonald, A., Buonaccorsi, G, Cheung, SW, Buckley, DL, Jackson, A-, Watson, Y, Davies, KE, Jayson, G-
Magnetic Resonance In Medicine. 2006;56.
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Full-text held externally
- DOI: 10.1002/mrm.21066
Abstract
Rapid T1-weighted 3D spoiled gradient-echo (GRE) data setswere acquired in the abdomen of 23 cancer patients during atotal of 113 separate visits to allow dynamic contrast-enhancedMRI (DCE-MRI) analysis of tumor microvasculature. The arterialinput function (AIF) was measured in each patient at each visitusing an automated AIF extraction method following a standardizedbolus administration of gadodiamide. The AIFs foreach patient were combined to obtain a mean AIF that is representativefor any individual. The functional form of this generalAIF may be useful for studies in which AIF measurementsare not possible. Improvements in the reproducibility of DCEMRImodel parameters (Ktrans, ve, and vp) were observed whenthis new, high-temporal-resolution population AIF was used,indicating the potential for increased sensitivity to therapyinducedchange. Magn Reson Med 56:000–000, 2006. © 2006Wiley-Liss, Inc.Key words: dynamic contrast-enhanced (DCE)-MRI; arterial inputfunction; tracer kinetic modeling; cancer