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Diffusion tensor MRI-based estimation of the inluence of brain tissue anisotropy on the effects of transcranial magnetic stimulation
De Lucia Marzia, Parker GJM, Embleton K, Newton J, Walsh Vincent
Neuroimage. 2007;36:1159-1170.
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Abstract
We evaluate and discuss the relevance of fiber anisotropy in estimatingthe effect of transcranial magnetic stimulation (TMS) on the humanbrain. Finite element simulations were carried out on a threedimensionalmodel of the head that included anisotropic conductivityinformation derived from diffusion tensor imaging (DTI).The results show that anisotropy has minor effects both on theposition of the main locus of activation and on its intensity. It has considerablymore effect on the spatial distribution of the induced electricfield, yielding differences of the order of 10% of the maximum inducedfield. Moreover the area affected by magnetic stimulation is slightlylarger when we include fiber anisotropy in the calculations than in anisotropic model. We also show that the induced field observed in theanisotropic model does not always align with the local fiber orientationbut rather follows specific patterns of parallelity.These findings will help to improve the estimation of the areasinvolved in magnetic stimulation.