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Optical virtual imaging at 50 nm lateral resolution with a white light nanoscope
Ashfaq Khan, BS Luk\'yanchuk, Lin Li, M Hong, W Guo, Z Chen, Zengbo Wang, Zhu Liu
Nature Communications. 2011;2(0):218-218.
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Abstract
The imaging resolution of a conventional optical microscope is limited by diffraction to ~ 200 nm in the visible spectrum. Efforts to overcome such limits have stimulated the development of optical nanoscopes using metamaterial superlenses, nanoscale solid immersion lenses and molecular fl uorescence microscopy. These techniques either require an illuminating laser beam to resolve to 70 nm in the visible spectrum or have limited imaging resolution above 100 nm for a white-light source. Here we report a new 50-nm-resolution nanoscope that uses optically transparent microspheres (for example, SiO 2, with 2 μ m < diameter < 9 μ m) as far-fi eld superlenses (FSL) to overcome the white-light diffraction limit. The microsphere nanoscope operates in both transmission and refl ection modes, and generates magnifi ed virtual images with a magnifi cation up to 8. It may provide new opportunities to image viruses and biomolecules in real time.
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