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Professor David Garrod (MA, PhD, FRSA) - publications

List of publications


  • Selina McHarg, Gemma Hopkins, Lusiana Lim,David Garrod. Down-regulation of desmosomes in cultured cells: the roles of PKC, microtubules and lysosomal/proteasomal degradation. P L o S Biology (Online), eScholarID:232760


  • Alexander Goonesinghe, Xing-Ming Luan, Adam Hurlstone and David Garrod. (In-press). Desmosomal cadherins in zebrafish epiboly and gastrulation. BMC Developmantal Biology, eScholarID:147892 | DOI:10.1186/1471-213X-12-1
  • Tsang, S.M., Liu, L., Teh, M.-T., Wheeler, A., Grose, R., Hart, I.R., Garrod, D.R., Fortune, F. & Wan. H. (In-press). Non junctional human desmoglein 3 acts as an upstream regulator of Src in E-cadherin adhesion, a pathway possibly involved in the pathogenesis of pemphigus vulgaris. Journal of Pathology, eScholarID:147893 | DOI:10.1002/path.3982


  • Nie, Z., Merritt, A., Rouhi-Parkouhi, M., Tabernero, L. & Garrod, D (2011). Membrane-impermeable cross-linking provides evidence for homophilic, isoform-specific binding of desmosomal cadherins in epithelial cells. J Biol Chem, 286(3), 2143-54. eScholarID:137127 | PMID:21098030 | DOI:10.1074/jbc.M110.192245


  • J.Zhang, J-M.Saint-Remy, D.R.Garrod, C.Robinson. (2009). Comparative enzymology of native and recombinant house dust mite allergen Der p 1. Allergy, 64, 469-477. eScholarID:1c8389 | DOI:10.1111/j.1398-9995.2008.01852.x
  • Michael Risley, David Garrod, Mark Henkemeyer, William McLean. (2009). EphB2 and EphB3 forward signalling are required for palate development. Mechanisms of Development, 126, 230-239. eScholarID:1c8445 | DOI:10.1016/j.mod.2008.10.009


  • Garrdo,D, Kimura, TE. (2008). Hyper-adhesion: a new concept in cell adhesion. Transactions of the Biochemical Society, xx, xx. eScholarID:1c7391 | DOI:10.1042/BST0360195
  • D.Garrod, C.Fisher, A.Smith , Z.Nie. (2008). Pervanadate stabilises desmosomes. Cell Adesion and Migration, 2, 161-166. eScholarID:1c8390 | DOI:10.4161/cam.2.3.6549
  • Garrod DD.R, Fisher C, Smith A, Nie Z. (2008). Pervanadate stabilizes desmosomes. Cell Adhesion and Migration, 2, 161-166. eScholarID:1d18579 | DOI:10.4161/cam.2.3.6549
  • A Scothern,D Garrod. (2008). Visualisation of desmosomes in the electron microscope. Methods in Cell Biology, 88, 347-367. eScholarID:1c8466 | DOI:10.1016/S0091-679X(08)00418-4


  • Merrit A. J., Kuichun Z., Garrod D.R., Chidgey M.A.J. (2007). A 4kb fragment of the desmocollin 3 promoter directs reporter gene expression to parakeratotic epidermis and primary hair follicles. Journal of Investigative Dermatology, 125, 243-247. eScholarID:1c6379
  • Kimura T. E., Merritt, A. J., Garrod, D. R. (2007). Calcium-independent desmosomes of keratinocytes are hyper-adhesive. Journal of Investigative Dermatology, 126, 775-781. eScholarID:1c6380 | DOI:10.1038/sj.jid.5700643
  • Garrod D. (2007). Cell adhesion and the extracellular matrix. In Goodman,S (Ed.), Medical Cell Biology. Elsevier. eScholarID:3c282
  • Garod,D, Chidgey, M. (2007). Desmosome structure composition and function. Biochimica et Biophysica Acta, xx, xx. eScholarID:1c7390 | DOI:10.1016/j.bbamem.2007.07.014
  • Zhang, J., J. M. Hamilton, D. R. Garrod, C. Robinson. (2007). Interactions between mature Der p 1 and its free prodomain indicate membership of a new family of C1 peptidases. Allergy, 62:, 1302-1309. eScholarID:1c7388 | DOI:10.1111/j.1398-9995.2007.01492.x
  • Runswick,S,Mitchell, T, Davies, P, Robinson, C, Garrod, DR. (2007). Pollen proteolytic enzymes degrade tight junctions. Respirology, 12(6), 834-842. eScholarID:1c7389 | DOI:10.1111/j.1440-1843.2007.01175.x
  • D.Garrod. (Ed.) (2007). Structure and Function in Cell Adhesion. Portland Press. eScholarID:4c157


  • Hardman MJ, Liu K, Avilion AA, Merritt A, Brennan K, Garrod DR, Byrne C. (2005). Desmosomal cadherin misexpression alters beta-catenin stability and epidermal differentiation. Molecular and cellular biology, 25(3), 969-78. eScholarID:1c4630 | PMID:15657425 | DOI:10.1128/MCB.25.3.969-978.2005
  • Garrod DR, Berika MY, Bardsley WF, Holmes D, Tabernero L. (2005). Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure. Journal of cell science, 118, 5743-5754. eScholarID:1c4626 | PMID:16303847 | DOI:10.1242/jcs.02700
  • Watson C, Hoare CA, Garrod DD.R, Carlson G.L, Warhurst G. (2005). Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores. Journal of Cell Science, 118(Pt 22), 5221-30. eScholarID:1d26657
  • Watson CJ, Hoare CJ, Garrod DR, Carlson GL, Warhurst G. (2005). Interferon-{gamma} selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores. Journal of cell science, 118(Pt 22), 5221-30. eScholarID:1c4629 | PMID:16249235
  • Garrod, D., Berika, M., Bardsley, W., Holmes, D. & Tabernero, L (2005). Hyper-adhesion in desmosomes: its regulation in wound healing and possible relationship to cadherin crystal structure. J Cell Sci, 118(Pt 24), 5743-54. eScholarID:137128 | PMID:16303847 | DOI:10.1242/jcs.02700


  • Garrod DR. (2004). Intercellular junctions in normal epidermis. Experimental dermatology, 13(10), 652-3. eScholarID:1c4628 | PMID:15447727 | DOI:10.1111/j.0906-6705.2004.0250b.x
  • Ainsworth PD, Winstanley JH, Pearson JM, Bishop HM, Garrod DR. (2004). Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma. European journal of cancer (Oxford, England : 1990), 40(15), 2269-73. eScholarID:1c4627 | PMID:15454252 | DOI:10.1016/j.ejca.2004.06.027
  • Smith C, Merritt A, Zhu K, Picton R, Youngs D, Garrod D, Chidgey M. (2004). Regulation of desmocollin gene expression in epidermis: CCAAT/enhancer binding proteins modulate early and late events in keratinocyte differentiation. Biochemical Journal, 380, 757-767. eScholarID:1c3544 | DOI:10.1042/BJ20040077
  • Hisamatsu Y, Amagai M, Garrod DR, Kanzaki T, Hashimoto T. (2004). The detection of IgG and IgA autoantibodies to desmocollins 1-3 by enzyme-linked immunosorbent assays using baculovirus-expressed proteins, in atypical pemphigus but not in typical pemphigus. The British journal of dermatology, 151(1), 73-83. eScholarID:1c4631 | PMID:15270874 | DOI:10.1111/j.1365-2133.2004.05995.x


  • Alazawi WOF, Morris LS, Stanley MA, Garrod DR, Coleman N. (2003). Altered expression of desmosomal components in high-grade squamous intraepithelial lesions of the cervix. Virchows Archives, 443, 51-56. eScholarID:1c3543 | DOI:10.1007/s00428-003-0771-9
  • McDermott JR, Bartram RE, Knight PA, Miller HR, Garrod DR, Grencis RK. (2003). Mast cells disrupt epithelial barrier function during enteric nematode infection. Proceedings of the National Academy of Sciences, 100(13), 7761-7766. eScholarID:1c1617 | PMID:12796512 | DOI:10.1073/pnas.1231488100
  • Baker SF, Yin Y, Runswick SK, Stewart GA, Thompson PJ, Garrod DR, Robinson C. (2003). Peptidase allergen Der p1 initiates apoptosis of epithelial cells independently of tight junction proteolysis. Molecular membrane biology, 20, 71-81. eScholarID:1c3542 | DOI:10.1080/0968768021000061150


  • Hiraki A, Shirasuna K, Ikari T, Shinohara M, Garrod DR. (2002). Calcium induces differentiation of primary human salivary acinar cells. Journal of cellular physiology, 193, 55-63. eScholarID:1c3541 | DOI:10.1002/jcp.10149
  • Garrod DR, Merritt AJ, Nie Z. (2002). Desmosomal adhesion: structural basis, molecular mechanism and regulation (Review). Molecular membrane biology, 19, 81-94. eScholarID:1c3539 | DOI:10.1080/09687680210132476
  • Garrod DR, Merritt AJ, Nie Z. (2002). Desmosomal cadherins. Current opinion in cell biology, 14, 537-545. eScholarID:1c3538 | DOI:10.1016/S0955-0674(02)00366-6
  • Nie Z, Hayashizaki Y, Garrod DD.R. Mus musculus mDsg2 and mRNA for desmoglein2, complete cds. 2002.
  • Merritt AJ, Berika MY, Zhai W, Kirk SE, Ji B, Hardman MJ, Garrod DR. (2002). Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation. Molecular and cellular biology, 22, 5846-5858. eScholarID:1c3540 | DOI:10.1128/MCB.22.16.5846-5858.2002


  • Runswick SK, O"Hare MJ, Jones L, Streuli CH, Garrod DR. (2001). Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nature cell biology, 3(9), 823-830. eScholarID:1c1948 | PMID:11533662 | DOI:10.1038/ncb0901-823
  • Chidgey M, Brakebusch C, Gustafsson E, Cruchley A, Hail C, Kirk S, Merrit A, North A, Tselepis C, Hewitt J, Byrne C, Fassler R, Garrod D. (2001). Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation. Journal of Cell Biology, 155, 821-832. eScholarID:1c3537 | DOI:10.1083/jcb.200105009
  • Robinson C, Baker SF, Garrod DR. (2001). Peptidase allergens, occludins and claudins. Do their interactions facilitate the development of hypersensitivity reactions at mucosal surfaces? Clinical and Experimental Allegy, 31, 186-192. eScholarID:1c3536 | DOI:10.1046/j.1365-2222.2001.01025.x
  • Wan H, Winton HL, Soeller C, Taylor GW, Gruenert DC, Thompson PJ, Cannell MB, Stewart GA Garrod DR, Robinson C. (2001). The transmembrane protein occluding of epithelial tight junctions is a functional target for serine peptidases from faecal pellets of Dermatophagoides pteronyssinus. Clinical and Experimental Allergy, 31, 279-294. eScholarID:1c3535 | DOI:10.1046/j.1365-2222.2001.00970.x
  • Chidgey, M., Brakebusch, C., Gustafsson, E., Cruchley, A., Hail, C., Kirk, S., Merritt, A., North, A., Tselepis, C., Hewitt, J., Byrne, C., Fassler, R. & Garrod, D (2001). Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation. J Cell Biol, 155(5), 821-32. eScholarID:137130 | PMID:11714727 | DOI:10.1083/jcb.200105009
  • Runswick, S., O'Hare, M., Jones, L., Streuli, C. & Garrod, D (2001). Desmosomal adhesion regulates epithelial morphogenesis and cell positioning. Nat Cell Biol, 3(9), 823-30. eScholarID:137129 | PMID:11533662 | DOI:10.1038/ncb0901-823


  • Wallis, S., Lloyd, S., Wise, I., Ireland, G., Fleming, T. & Garrod, D (2000). The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells. Mol Biol Cell, 11(3), 1077-92. eScholarID:137131 | PMID:10712521