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Professor Rayaz Malik (BSc (hons)., MSc., MBChB, FRCP, PhD) - research

Research interests

Light and electron microscopic morphometry to quantify pathology and apoptosis in relation to the severity and symptoms of peripheral neuropathy and the pathophysiology of: diabetic amyotrophy, Insulin neuritis, IGT neuropathy, Carpal Tunnel syndrome.

Atrial appendage material has been collected from diabetic and non-diabetic patients undergoing either valve replacement or CABG in the Manchester Heart Centre for defining the expression of key angiogenic molecules: VEGF, VEGFr, HIF-1, in relation to atrial cardiomyocyte and vascular morphology to help define the molecular basis of diabetic cardiomyopathy.

We have performed sequential biopsies from chronic non-healing foot ulcers and acute wounds in the upper arm to define the genomic differences between human acute and chronic wounds employing tissue genomic profiling using micro array ‘chip’ technology in collaboration with Renovo Limited, Manchester Incubator Building, University of Manchester.

Collaborators and affiliated staff

  • Professor David Tomlinson, Faculty of Life Sciences, University of Manchester
  • Dr Maria Jeziorska, Division of Regenerative Medicine, University of Manchester
  • Professor Solomon Tesfaye, Royal Hallamshire Hospital, Sheffield, UK
  • Dr Gerry Rayman, Ipswich Hospital, UK
  • Professor Nathan Efron, Brisbane, Australia
  • Professor D Zochodne, University of Calgary, Canada
  • Professor L Dahlin, University of Malmao, Sweden
  • Professor D Ziegler, Dusseldorf, Germany
  • Professor D Yue, Sydney, Australia

Methodological knowledge

Techniques.

In-vivo studies.

State of the art facilities employing quantitative sensory testing, electrophysiology, corneal confocal microscopy and iontophoresis with scanning laser Doppler imaging to conduct in-vivo physiological studies characterising the severity of neuro-vascular damage in diabetic patients.

In-vitro studies.

A fully functional laboratory to perform both gluteal subcutaneous, and foot skin biopsies and in-vitro myography on resistance arteries in patients is established.

Laboratory based studies.

In 1993, I established the protocol to carry out tissue processing and detailed light and electronmicroscopy with quantitative assessment of nerve and cardiac tissue pathology in the electronmicroscope unit. This has now been further developed to combine morphometry with immunohistological studies.