Professor Yanick Crow (BMedSci, MBBS, MRCP, PhD) - personal details

I qualified in Medicine from Newcastle University in 1991, obtained my MRCP in adult medicine in Glasgow, subsequently worked in paediatrics in Stirling, and then undertook training in Clinical Genetics at Yorkhill Hospital (1996 - 1999). Inspired by Professor John Stephenson and Dr John Tolmie I became interested in neurogenetics and moved to Leeds where I undertook a PhD on the genetics of Aicardi-Goutières syndrome (AGS) with Dr Geoff Woods and Sir Alex Markham. Between 2001 and 2006 I was a full-time NHS consultant in the Yorkshire Regional Genetics Service, at which point I took up a post as Senior Lecturer in the Leeds Institute of Molecular Medicine working closely with Professor David Bonthron. In 2008 I became a Professor in Genetic Medicine at the University of Manchester.

My work has two main themes:

1. The pathogenesis of the complex disorder systemic lupus erythematosus (SLE).

2. Paediatric neurogenetics.

My work on Aicardi Goutieres syndrome has proved of considerable scientific interest by defining novel pathways linking nucleic acid metabolism with the immune system. Consequently, we are now studying other Mendelian forms of SLE.

Additionally, taking intracranial calcification as a diagnostic starting point has allowed for the delineation of a number of other clinical entities, demonstrating this same radiological sign, the genetic basis of which are currently under investigation.