![MSc Medical Imaging Science at The University of Manchester](http://contentlibrary.manchester.ac.uk/_coursemarketing/UMANC/2024/205/10263/U_medicalimagingscience_1400x450.jpg)
Course unit details:
Advanced PET and MRI
Unit code | IIDS67432 |
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Credit rating | 15 |
Unit level | FHEQ level 7 – master's degree or fourth year of an integrated master's degree |
Teaching period(s) | Semester 2 |
Available as a free choice unit? | No |
Overview
The unit will give a comprehensive overview of PET methods and will be broadly organised into two areas:
PET Image processing
- Recapitulation on PET instrumentation, image formation and reconstruction
- Properties of PET images
- PET image analysis (registration, filtering, partial volume correction, Statistical Parametric Mapping)
Kinetic modelling of dynamic PET images
- Blood data radioactivity measurement and the estimation of an input function (well counters, continuous blood measurements, raidoHPLC)
- Kinetic modelling methofds (graphical methods such as Patlak/Logan, compartmental modelling, reference tissue methods)
With example applications and supplementary methods:
- Neuroscience applications and head motion (activation studies)
- In-vivo pathology (amyloid & tau imaging, neurotransmitter release)
- Use in drug development for the central nervous system
The unit will also review the physics of MR image formation and present a range of advanced and cutting-edge quantitative MR imaging methods.
- Recap of MP image formation - basica physics, relaxation processes, contrast mechanisms, MR image pulse sequencess and k-space, fast imaging seequences
- Quantitative relaxation time imgaging
- Non-contrast methods to imaging blood flow and prefusion - angiography, phase-contrast flow, arterial spin labelling
- Use of MR contrast agents, qualitative perfusion - angiography, phase-contrat flow, arterial spin labelling
- Use of MR contrast agens, qualitiative perfusion-weighted methods and quantitative modelling of dynamic contrast-enhanced MRI
- Functional MR imaging using BOLD contrast
- Diffusion-weighted MR imaginng and tractography
- Spectroscopy, non-proton imaging methods
The lectures will be supplemented by recommended text.
Pre/co-requisites
Students are required to have attended Mathematical Foundations of Imaging and Radioisotope Imaging in order to study this unit.
Aims
- To provide the student with knowledge of the breadth and depth of what can be done using Positron Emission Tomography, with emphasis on the methods available and their application to study the normal diseased brain.
- To provide a suitable depth of knowledge regarding quantification of brain PET images that enables the student to understand and appraise the PET imaging literature.
- To equip students with a comprehensive understanding of the basic principles of magnetic resonance image formation in terms of the underlying physics.
- To develop an awareness of the range of MR techniques for quantitative imaging and selected clinical and research applications for the brain.
- To enhance the students' abilities in experimental research methods including critical appraisal of scientific literature and data acquisition, analysis and reporting, providing a foundation for further research and employment in academic or industrial settings.
Learning outcomes
Category of outcome | Students will: | ||||||||||||||||
Knowledge and understanding |
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Intellectual skills |
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Practical skills |
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Transferable skills and personal qualities |
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