Developing a novel collagen model to improve the treatment of diabetic foot ulcers.

Diabetes has major implications for public health. Diabetic foot ulcers (DFUs) affect 20% of patients, with around half of these becoming infected, which can, ultimately, lead to amputation.
Biocomposites wanted to investigate the potential use of calcium sulfate beads to release antibiotics directly into infected tissues to determine how effective this would be in clearing bacterial biofilm. However, existing in vitro models were costly and of limited relevance to human soft tissue, so were not suitable for testing in detail the performance of the Biocomposites technology.