MSc Model-based Drug Development - Pharmacokinetic and Pharmacodynamic Modelling
Year of entry: 2025
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Course unit details:
Advanced Research Topics and Project Development in Modelling and Simulation
| Unit code | PHAR69924 |
|---|---|
| Credit rating | 15 |
| Unit level | FHEQ level 7 – master's degree or fourth year of an integrated master's degree |
| Teaching period(s) | Semester 2 |
| Available as a free choice unit? | No |
Overview
This unit focuses on current problems in drug development that are being addressed with the help of modelling and simulation. Students are presented with case studies (lectures and tutorial sessions) that highlight the value of pharmacometric modelling and innovations in modelling methods. Students will conduct a literature review and critique of a focussed area of pharmacometrics, modelling and simulation and will construct a modelling project proposal which will usually provide the basis for the MSc dissertation after completion of this unit.
Pre/co-requisites
| Unit title | Unit code | Requirement type | Description |
|---|---|---|---|
| Basic Pharmacokinetics and Pharmacodynamics | PHAR69921 | Pre-Requisite | Compulsory |
| PBPK and In Vitro In Vivo Extrapolation (IVIVE) (1) Fundamental Concepts | PHAR69922 | Pre-Requisite | Compulsory |
| Data Analysis in Pharmacokinetics and Pharmacodynamics | PHAR69923 | Pre-Requisite | Compulsory |
Aims
The unit aims to:
- expose the student to recent advances, controversies, and expectations in the application of pharmacometric modelling and simulation to drug development and related clinical problems
- give examples showing how modelling produces clinical, commercial, or population health benefits
- identify good practice in the conduct of modelling and simulation projects, from inception and preparation of a proposal to the interpretation and communication of results.
Teaching and learning methods
- Lectures.
- Tutorials.
- Directed reading.
- Written assignments.
Knowledge and understanding
- Give examples showing the contribution of modelling and simulation to drug development.
- Show awareness of a wide range of applications of pharmacometric modelling.
Intellectual skills
- Evaluate journal articles describing modelling and simulation projects.
- Identify good and bad practice in modelling and simulation projects.
- Recognise common modelling principles in a wide range of research and drug development situations.
- Recognise the key elements of a convincing research proposal.
Practical skills
- Construct a focussed critical review of scientific literature in a specific area, exhibiting good writing and referencing skills.
- Construct a project plan showing awareness of important objectives, possible limitations and dependencies, time and resource constraints.
Transferable skills and personal qualities
- Extracting key points from scientific literature.
- Effective written communication.
- Project planning.
Assessment methods
| Method | Weight |
|---|---|
| Report | 100% |
Feedback methods
Feedback will be given after the exam board.
Study hours
| Scheduled activity hours | |
|---|---|
| Lectures | 10 |
| Seminars | 10 |
| Independent study hours | |
|---|---|
| Independent study | 280 |
Teaching staff
| Staff member | Role |
|---|---|
| Kayode Ogungbenro | Unit coordinator |