PG Credit Genomic Medicine CPD
Year of entry: 2023
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Course unit details:
Disease Modelling and Genome Engineering
|Unit level||FHEQ level 7 – master's degree or fourth year of an integrated master's degree|
|Teaching period(s)||Semester 2|
|Offered by||School of Biological Sciences|
|Available as a free choice unit?||Yes|
This unit will provide essential and contemporary knowledge on the importance of using model systems to investigate the functional genomics of inherited human diseases. The unit will also review genomic engineering technologies and provide a workshop for the design of CRISPR-Cas9 reagents.
Students will be provided with a number of example engineered models to study human disease and will be able to understand the merits and drawbacks of many of the cell and animal models available to researchers. The ethics of using animal models and the potential of genomic engineering to alter human genomes will also be discussed.
The unit is led and delivered by academics with a wealth of experience in using a wide range of models to study human genetic disease.
- Provide an understanding of why animal and cellular models are necessary for studying the functional genomics of human disease.
- Provide an understanding of the different model systems available for studying human disease.
- Provide an understanding of how to manipulate gene expression in a variety of model systems.
- Provide an understanding of the genome engineering techniques available, how to design associated reagents, and how to use them.
- Provide an understanding of the ethical considerations associated with animal models and genome engineering.
- Be able to use literature and online resources to access information on disease modelling and genomic engineering.
- Be able to apply knowledge of model systems and genome engineering to critically analyse published data and to design experiments.
Teaching and learning methods
This module will be delivered over a one week period and consists of a series of face to face lectures, interactive seminars, and computer practicals. Lectures are supported with online resources and/or key references.
Knowledge and understanding
- Use advanced knowledge in how to manipulate the genomic sequence and gene expression of cell and animal models to evaluate models of human disease.
- Use advanced knowledge in how to manipulate the genomic sequence and gene expression of cells, animals and humans to evaluate therapeutic treatments for inherited human disease.
- Describe and critically evaluate a range of contemporary genomic technologies to alter the sequence and expression of genes.
- Debate the ethical arguments about the use of animal models to study human disease and the ethical concerns about being able to alter genomes in vitro and in vivo.
- Critically evaluate the methods and technologies used to generate model systems of inherited human diseases.
- Critically evaluate the methods and technologies used to generate therapies employing altered gene expression for the treatment of inherited human diseases.
- Review and critically anayse the scientific literature relevant to model systems and genomic engineering pertinent to inherited human disease.
- Present a case from the literature on a model system, or treatment, of an inherited human disease.
- Use web-based tools to design regents to alter the expression of genes or genomic sequence.
Transferable skills and personal qualities
- Develop problem solving skills through collaboration in group working and debate.
- Enhance oral and written presentation skills.
|Written assignment (inc essay)||60%|
Written Feedback with 15 working days
- Housden et al.. Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. Nat Rev Genet. 2017 Jan;18(1):24-40.
Mandai et al.. Autologous Induced Stem-Cell-Derived Retinal Cells for Macular Degeneration. N Engl J Med. 2017 Mar 16;376(11):1038-1046.
- Normile D. iPS cell therapy reported safe. Science. 2017 Mar 17;355(6330):1109-1110.
- Ledford H. CRISPR, the disruptor. Nature. 2015 Jun 4;522(7554):20-4.
- Liang et al.. Developmental history and application of CRISPR in human disease. J Gene Med. 2017 Jun 17.
- Chandrasekaran et al. Genome editing: a robust technology for human stem cells. Cell Mol Life Sci. 2017 Apr 12.
- Lanphier et al.. Don't edit the human germ line. Nature. 2015 Mar 26;519(7544):410-1.
- Ishii T. Germline genome-editing research and its socioethical implications. Trends Mol Med. 2015 Aug;21(8):473-81.
|Independent study hours|
|Forbes Manson||Unit coordinator|