PhD/MPhil Medical Genetics

Visit our Faculty of Biology, Medicine and Health Postgraduate Research page to find out about upcoming open days and events.

Apply online

Before applying you must:

• Choose a programme or find a project you want to apply for and check you’re eligible.
• Speak to the listed supervisor about your suitability for their project or programme.
• Understand how your project is funded and, if it is self-funded, consider how you plan on funding it.
• Read our ‘How to apply’ page to find out more and ensure you include all required supporting documents at the time of submission.

Visit our Faculty of Biology, Medicine and Health Postgraduate Research page to find out more.

Before you start your application, you should:

• Identify the programme or find the specific research project you'd like to apply for.
• Contact the listed project supervisor and speak to them about your suitability for the project.
• Understand how your project is funded or, if you are self-funding, you should have an idea of how you are funding your project and have discussed this with your supervisor.

If you already have funding:

• Find a specific self-funded project and contact the project supervisor to talk to them about your suitability for the project; OR
• Determine your own research project and title, find a potential supervisor in this research area and contact them to discuss supervising your research.

Supporting documents

You'll also need to make sure you have the following documents before you apply:

• Personal statement
• Certificates and transcripts
• CV
• Confirmation of funding (if you are self-funded)
• English language ability
• Names and details of two referees to support your application

Visit our ‘How to apply’ page to find out more about the information required for each of these supporting documents.

Any missing information may delay the processing of your application.

Application deadlines

You must submit your application for a postgraduate research programme before the relevant deadline to be considered. You will not be able to apply after these deadlines have passed.

• January entry: 15 October (of the year prior entry)
• April entry: 15 January (year of entry)
• September entry: 15 June (year of entry)

Our PhD/MPhil Medical Genetics programme enables you to undertake a research project that will improve understanding of Medical Genetics.

The field of genomic medicine integrates basic and clinical research. At a genetic level, the aim is to identify the genetic basis of both single gene and complex disorders.

This includes studying the normal role of the genes and proteins that have been identified, as well as understanding the functional consequences of pathogenic genetic variants.

Ultimately, the aim is to translate this research knowledge into healthcare benefits, including improved diagnosis and management, as well as, ultimately, into new treatment methods for the conditions investigated.

The University of Manchester has internationally-recognised expertise in several areas of genomic medicine that include the following:

• Biochemical genetics: Diagnosis, research and development of treatmentsof a range of metabolic and lysosomal diseases, including mucopolysaccharide diseases.
• Developmental genetics: The main aim is to understand the cellular and molecular processes behind both normal development and genetic disease and to improve diagnosis and management of human genetic disorders and birth defects. Manchester leads the European Reference Network for this group of disorders. Major programs of work include studies on the genetic basis and molecular treatment of visual impairment; chromatin remodelling disorders, including Kabuki syndrome.
• Health services research in genetics: Qualitative and quantitative programmes focused around the evaluation of genetics clinical services and the psychosocial impact of genetic disease.
• Cancer genetics: Includes research into the inherited forms of breast and colorectal cancer. We also have specific interests in neurofibromatosis and schwannomatosis linked to nationally commissioned clinical services.
• Neurogenetics: Includes conditions encountered in paediatric neurogenetic practice, with the aim of improving the diagnosis, management and, ultimately, treatment of these disorders. Particular expertise has been developed in the study of Aicardi-Goutières syndrome.
• Inflammatory disorders: rare Mendelian forms of inflammation can provide insight into common disorders including systemic lupus erythematosis.
• Renal genetics: studies on the lower urinary tract include characterising bladder disorders including urofacial syndrome and bladder exstrophy. Expertise is considerable in renal cystic disease and induced pluripotent stem cell (iPSC) modelling.
• Cardiac Genetics: Studies on the rare inherited heart rhythm disorder catecholaminergic polymorphic ventricular tachycardia include variant characterisation and treatment modelling using iPSC.
• Pharmacogenetics: study of how genetic variation can result in different responses to medication and how to avoid adverse reactions in clinical practice and the effects of medication taken in pregnancy on the developing fetus.
• Ophthalmic genetics: studies on Mendelian and complex conditions including retinal and corneal dystrophies and age-related macular degeneration. Expertise in bioinformatic analysis of next generation sequencing data, and functional and treatment modelling using induced pluripotent stem cells (iPSC).

State-of-the-art genomic technologies including exome and genome sequencing are employed in the centre to facilitate the work.

Training and development

All of our postgraduate researchers attend the Doctoral Academy Training Programme delivered by the Researcher Development team . The programme provides key transferable skills and equips our postgraduate researchers with the tools to progress beyond their research degree into influential positions within academia, industry and consultancy. The emphasis is on enhancing skills critical to developing early-stage researchers and professionals, whether they relate to effective communication, disseminating research findings and project management skills.

PhD/MPhil programmes are based on individual research projects that last three to four years (PhD) or one to two years (MPhil), working with a specific Primary Supervisor and Co-Supervisor(s).

Applicants are specifically matched with a Primary Supervisor and individual project based on their research interests and background.

International applicants interested in this research area can also consider our PhD programme with integrated teaching certificate .

This unique programme will enable you to gain a Postgraduate Certificate in Teaching and Learning, whilst also carrying out independent research on your chosen project.

Find out more about what it's like to undertake a postgraduate research degree at Manchester on the Doctoral Academy Blog and the support available through our Faculty Doctoral Academy.

You will have access to a range of  research and learning facilities  across the University and at some of our partner organisations.

Your postgraduate research degree will open up a range of career opportunities after you graduate. Find out more on the  Careers  page.