![MSci Biochemistry at The University of Manchester](http://contentlibrary.manchester.ac.uk/_coursemarketing/UMANC/2024/202/10110/U_msci3_1400x450.jpg)
- UCAS course code
- 2C13
- UCAS institution code
- M20
Course unit details:
Biochemical Basis of Disease (E)
Unit code | BIOL31332 |
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Credit rating | 10 |
Unit level | Level 3 |
Teaching period(s) | Semester 2 |
Available as a free choice unit? | No |
Overview
Major diseases of man such as diabetes, obesity, atherosclerosis, and fibrosis, are increasingly significant contributors to morbidity and mortality in the western world. Developing treatments for these diseases is a major challenge to the pharmaceutical industry and there is great interest in the biochemistry underlying their pathogenesis.
Pre/co-requisites
Unit title | Unit code | Requirement type | Description |
---|---|---|---|
Cell Metabolism & Metabolic Control | BIOL21132 | Pre-Requisite | Recommended |
Aims
This unit aims to describe the biochemistry of these common diseases and highlight how our current understanding of disease mechanisms informs the development of novel therapies.
Learning outcomes
Students should have an understanding of the biochemical basis of a number of major diseases of man and appreciate how and why specific disease mechanisms are being targeted in the development of new treatments.
Syllabus
A significant proportion of this course will be delivered in the form of directed reading supported by lectures and will focus on biochemical aspects of disease mechanisms and potential therapies relating to:
Diabetes and Obesity: metabolic syndrome, beta cells and insulin secretion, insulin resistance, type II diabetes, secondary complications of diabetes.
Vascular disease: Atherosclerosis, dyslipidaemia, vascular calcification, aberrant angiogenesis.
Fibrotic disease: ECM biology in tissue homeostasis, remodelling, repair and fibrosis.
Aberrant TGF-beta signalling: Lung fibrosis and Marfan Syndrome.
Protein folding/misfolding diseases: amyloid diseases, prion disease, gain and loss of function.
Employability skills
- Research
- Students encouraged to read around the lecture material including recommended primary literature and review papers.
- Written communication
- Students have the opportunity to submit and receive feedback on an exam style essay outline which is based on relevant questions from past papers.
Assessment methods
Method | Weight |
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Other | 10% |
Written exam | 70% |
Oral assessment/presentation | 20% |
Written exam (1-hour 45 minute) synchronous online exam answering one essay question from a choice of 3) 70%
Oral assessment/presentation 20%
MCQ online assessment (4 x 2.5%) 10%
Feedback methods
Group feedback will be given for the assessment and an online discussion forum on Blackboard or Padlet will be available to facilitate communication amongst students and teaching staff.
The final lecture of the course will be attended by all lecturers. The focus will be to provide a review of the previous year’s exam paper and guidance on exam preparation.
Recommended reading
Review papers and some primary literature will be provided on Blackboard to compliment the lecture topics.
Study hours
Scheduled activity hours | |
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Assessment written exam | 2.8 |
Lectures | 18 |
Independent study hours | |
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Independent study | 79.2 |
Teaching staff
Staff member | Role |
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Susan Taylor | Unit coordinator |