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MSc Model-based Drug Development / Course details

Year of entry: 2020

Course unit details:
Advanced Research Topics and Project Development in Modelling and Simulation

Unit code PHAR69924
Credit rating 15
Unit level FHEQ level 7 – master's degree or fourth year of an integrated master's degree
Teaching period(s) Semester 2
Offered by Pharmacy
Available as a free choice unit? No

Overview

This unit focuses on current problems in drug development that are being addressed with the help of modelling and simulation. Students are presented with case studies (lectures and tutorial sessions) that highlight the value of pharmacometric modelling and innovations in modelling methods. Students will conduct a literature review and critique of a focussed area of pharmacometrics, modelling and simulation and will construct a modelling project proposal which will usually provide the basis for the MSc dissertation after completion of this unit.

Pre/co-requisites

Unit title Unit code Requirement type Description
Basic Pharmacokinetics and Pharmacodynamics PHAR69921 Pre-Requisite Compulsory
PBPK and In Vitro In Vivo Extrapolation (IVIVE) (1) Fundamental Concepts PHAR69922 Pre-Requisite Compulsory
Data Analysis in Pharmacokinetics and Pharmacodynamics PHAR69923 Pre-Requisite Compulsory

Aims

The unit aims to:

·      Expose the student to recent advances, controversies, and expectations in the application of pharmacometric modelling and simulation to drug development and related clinical problems.

·      Give examples showing how modelling produces clinical, commercial, or population health benefits.

·      Identify good practice in the conduct of modelling and simulation projects, from inception and preparation of a proposal to the interpretation and communication of results.

Teaching and learning methods

· Lectures

· Tutorials

· Directed reading

· Written assignments

 

Knowledge and understanding

·   Give examples showing the contribution of modelling and simulation to drug development

·   Show awareness of a wide range of applications of pharmacometric modelling. 

Intellectual skills

·   Evaluate journal articles describing modelling and simulation projects

·   Identify good and bad practice in modelling and simulation projects.

·   Recognise common modelling principles in a wide range of research and drug development situations.

-   Recognise the key elements of a convincing research proposal

Practical skills

·  Construct a focussed critical review of scientific literature in a specific area, exhibiting good writing and referencing skills

  -   Construct a project plan showing awareness of important objectives, possible limitations and dependencies, time and resource constraints

Transferable skills and personal qualities

·     extracting key points from scientific literature

·     effective written communication

·     project planning

Assessment methods

Method Weight
Written exam 40%
Report 40%
Oral assessment/presentation 20%

Feedback methods

Feedback will be given after the exam board

Study hours

Scheduled activity hours
Lectures 10
Seminars 10
Independent study hours
Independent study 280

Teaching staff

Staff member Role
Amin Rostami-Hochaghan Unit coordinator

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