MSc Clinical Immunology

Year of entry: 2021

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Course unit details:
Advanced Clinical Immunology

Unit code MEDN63320
Credit rating 30
Unit level FHEQ level 7 – master's degree or fourth year of an integrated master's degree
Teaching period(s) Full year
Offered by Division of Medical Education
Available as a free choice unit? No

Overview

This is a 30-credit unit, which comprises three components each of a notional 10 credits.   Each component covers a distinct element of Clinical Immunology: Hypersensitivity & Allergy, Haematological Malignancy, and  Autoimmunity.

Hypersensitivity & Allergy

This component will provide the student with knowledge and understanding of the mechanism of hypersensitivity and allergy. They will understand the clinical presentation and investigation of a range of associated conditions. They will become familiar with methods and strategies to investigate hypersensitivity and allergy and gain experience of the interpretation of patient results in a variety of clinical settings.

Haematological Malignancy

This component equips students with knowledge and understanding of the pathophysiology, clinical presentation and management of patients with haematological malignancies and the interpretation of appropriate diagnostic investigations. Furthermore, it will provide students with knowledge of the scientific basis and an understanding of principles and practice of stem cell and bone marrow transplantation.

Autoimmunity

This component will provide the student with knowledge and understanding of the mechanisms of autoimmunity. They will understand the clinical presentation and investigation of a range of autoimmune diseases. They will become familiar with methods and strategies to investigate autoimmunity and gain experience of the interpretation of patient results using a variety of clinical scenarios.

Aims

The aims of this unit are to provide students with a good understanding of the mechanisms, pathology and clinical investigation of each disease area covered by the three distinct components.

Teaching and learning methods

Lectures, seminars and clinical case discussions.

 

Knowledge and understanding

Hypersensitivity and Allergy

•       Define and explain ‘atopy’ and the factors involved in the development of atopic disease

•       Define and explain allergy, distinguishing it from hypersensitivity

•       Explain and distinguish between the four types of hypersensitivity

•       Explain the production of immunoglobulin E (IgE) by B cells in response to allergen

•       Explain how IgE triggers mast cells to degranulate and describe the clinical features of mast cell degranulation in the allergic patient

•       Discuss the important features of allergic rhinitis, atopic eczema and anaphylaxis

•       Describe the design, operation and performance of hypersensitivity skin testing, including contraindications, limitations and precautions to be taken

•       Describe the design, operation, use and limitations of immunology laboratory tests for specific IgE

•       Discuss the important causes of and explain the mechanism of allergic contact dermatitis

•       Describe the partnership between the clinical immunology laboratory and other clinical specialisms in the investigation of hypersensitivity and allergy and patient care

 

Haematological Malignancy

•       Explain the classification, aetiology and genetics of haematological malignancy

•       Describe the design, operation and performance of laboratory and molecular techniques used in the investigation and management of haematological malignancy

•       Discuss the principles of bone marrow and stem cell harvests and their role in transplantation programmes

•       Discuss the principles and mechanisms of chemotherapy, immunotherapy and radiotherapy and their use in haematological malignancy

•       Explain the importance and implementation of national (e.g. NICE) guidance on the diagnosis and management of haematological cancer

•       Discuss the importance of integrated diagnosis of haematological malignancy

•       Describe the partnership between the haematology laboratory and other clinical specialisms in the investigation of haematological malignancy and patient care

 

Autoimmunity

•       Explain the causes of autoimmune disease

•       Discuss and justify the strategies and methods to distinguish autoimmunity from autoimmune disease

•       Explain the role of autoantibodies and autoimmune disease

•       Explain the role of autoreactive T cells and autoimmun

Intellectual skills

  • Critically analyse scientific and clinical data
  • Present scientific and clinical data appropriately
  • Formulate a critical argument
  • Evaluate scientific and clinical literature
  • Apply the knowledge of clinical immunology to address specific clinical problems

Practical skills

  • Present information clearly in the form of verbal and written reports
  • Communicate complex ideas and arguments in a clear and concise and effective manner
  • Work effectively as an individual or part of a team
  • Use conventional and electronic resources to collect, select and organise complex scientific information

Transferable skills and personal qualities

  • Present complex ideas in simple terms in both oral and written formats
  • Consistently operate within sphere of personal competence and level of authority
  • Manage personal workload and objectives to achieve quality of care
  • Actively seek accurate and validated information from all available sources
  • Select and apply appropriate analysis or assessment techniques and tools
  • Evaluate a wide range of data to assist with judgements and decision making
  • Interpret data and convert into knowledge for use in the clinical context of individual and groups of patients

Assessment methods

Method Weight
Written exam 73%
Written assignment (inc essay) 13.5%
Oral assessment/presentation 13.5%

Feedback methods

Marks will be provided online within 15 working days of assessment deadline

Study hours

Independent study hours
Independent study 300

Teaching staff

Staff member Role
Nicholas Barnes Unit coordinator

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