MChem Chemistry with Medicinal Chemistry

This unit addresses core material covering the bonding, structure and reactivity of inorganic systems of the s- and p-block elements, and organometallic chemistry across the periodic table.

On successful completion of the course students should be able to:

• understand the origin of the periodic trends in the s- and p-block and apply knowledge of these trends to solve chemical problems.
• understand and apply the various bonding models and concepts relevant to main group compounds including: hard-soft acid base theory, Lewis acids/bases, solution speciation, valency vs. oxidation state, delocalised bonding, Wade’s rules, inorganic aromaticity, weakly coordinating anions.
• understand, and be able to apply to chemical problems, the key electron counting methods, reaction types and bonding models of d-block organometallic compounds.
• understand the synthetic routes, bonding and general reactivity pathways of d-block compounds containing M-C bonds.
• utilise spectroscopic data to identify organometallic structures.

Periodicity and s- and p-block Chemistry, 14 lectures/workshops

Content:

• Periodic and Group trends in the periodic table with a primary focus on the s and p block

• Hydrides, Halides and Oxides of the s and p-block elements

• Organometallic chemistry of the s block

• Main Group Lewis acids and bases

• Wades Rules applied to Polyhedral Boranes, Carboranes and Zintl Ions

• Halide chemistry and Weakly Coordinating Anions

Organometallic Chemistry of the d block, 10 lectures/revision seminars

Content:

• 18 and 16 electron rules and electron counting conventions

• Complexes of key ligands and synergistic bonding

• Principal reaction types in organometallic chemistry

• Synthesis, bonding and reactivity of d block metal-carbon bonds

• Organometallic reaction mechanisms and catalytic processes.

• Spectroscopic properties of Organometallic complexes

On successful completion of the course students should be able to: - understand the origin of the periodic trends in the s- and p-block elements and compounds and apply knowledge of these trends to solve chemical problems. - understand and apply the various bonding models and concepts relevant to main group compounds including: hard-soft acid base theory, Lewis acids/bases, solution speciation, valency vs. oxidation state, delocalised bonding, Wade’s rules, inorganic aromaticity, weakly coordinating anions. - understand, and be able to apply to chemical problems, the key electron counting methods, reaction types and bonding models of d-block organometallic compounds. - understand the synthetic routes, bonding and general reactivity pathways of d-block compounds containing M-C bonds. - utilise spectroscopic data to identify organometallic structures.

Feedback will be available via the following methods:

• during workshop sessions, when staff will be available to answer questions and provide help;

• via attendance and participation in tutorials, including submission of problem sheets;

• staff office hours

• formative online quizes

• C.E Housecroft and A. G Sharpe, Inorganic Chemistry (3rd Ed), Pearson

• Shriver and Atkins, Inorganic Chemistry (5th Edition), Oxford

• N. C. Norman, Periodicity and the s- and p-block elements, Oxford Primer No 51

Available online free to Manchester Students online via Bibliotech

• J. Keeler and P. Wothers, Chemical structure and Reactivity, (2nd Ed.) Oxford

• M. Bochmann,'Organometallics 1' and 'Organometallics 2', Oxford Chemistry Primers, Nos. 12 and 13 (Available online free to Manchester students via Bibliotech)

• A.F. Hill, 'Organotransition metal chemistry' RSC Tutorial Text No. 7.

Scheduled activity hours Assessment written exam 2 Lectures 11 Practical classes & workshops 13 Tutorials 3

Teaching staff

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