Year of entry: 2022
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Course unit details:
Molecules and Cells in Human Disease
|Unit level||Level 2|
|Teaching period(s)||Semester 1|
|Offered by||School of Biological Sciences|
|Available as a free choice unit?||No|
You will learn about the basic cellular mechanisms underlying common human diseases and understand how drugs act on cellular and tissue dysfunctions to treat these diseases. You will study topics including autoimmune disease, cancer and arthritis.
|Unit title||Unit code||Requirement type||Description|
|From Molecules to Cells||BIOL10232||Pre-Requisite||Recommended|
|Drugs: From Molecules to Man||BIOL10822||Pre-Requisite||Recommended|
To introduce cellular and molecular mechanisms of human disease.
Students will acquire knowledge of the basic cellular mechanisms underlying common human diseases and will understand how drugs act on cellular and tissue dysfunctions to ameliorate these diseases.
The course examines the cellular and molecular causes of a wide variety of human diseases such as diabetes and cancer. It aims to show how understanding a disease at the molecular level explains its pathology and allows the design of therapeutic strategies. Specific topics will include:
- Cell death mechanisms and disease
- Cell adhesion and its pathological defects of connective tissues
- Type 1 and 2 diabetes
- Biochemical complications of diabetes and therapies
- Inflammation and anti-inflammatory drugs
- Molecular pathology of cancer
- Cancer chemotherapy
Each set of lectures will be followed by an online quiz to provide formative feedback on your understanding of the material
A graphical exercise on diabetes will be provided on Blackboard. This includes example essay and short answer questions on the subject of diabetes and its pharmacology.
- Students have to carry out additional reading for each lecture.
- Meeting multiple deadlines. Students have a number of on line activities to completes, with fixed deadlines. Students have to manage these deadlines.
Written Exam worth 90% of the final unit mark, eLearning activities worth 10% of the final unit mark.
The eLearning activities will provide on line feedback. Advice on the example exam questions on the eLearning resource will be provided if requested. Feedback will be given on the MCQ assessment before the end of the course. Post-exam guidance will be provided.
A formative mid-semester miniexam
A formative mock exam
The following general texts will provide useful background include. However, no one textbook will cover all the material presented in the lectures, due to the diverse nature of the course. Each lecturer will therefore provide specific reference articles for their lecture material.
- Alberts B, Johnson A, Lewis J, Raff M, Roberts K & Walter P, Molecular Biology of the Cell (6th edition), Garland Science, 2015, Recommended
- Cassimeris, Lingappa, Plopper, Lewin's Cells (3rd edition), Jones and Bartlett, Recommended
- Rang HP, Ritter JM & Flower, R, and Henderson Rang & Dale's Pharmacology (8th Edition), Elsevier, Recommended
|Scheduled activity hours|
|Assessment written exam||2|
|Independent study hours|
|Andrew Gilmore||Unit coordinator|