
- UCAS course code
- C724
- UCAS institution code
- M20
Course unit details:
Protein Assembly, Dynamics & Function (E)
Unit code | BIOL31311 |
---|---|
Credit rating | 10 |
Unit level | Level 3 |
Teaching period(s) | Semester 1 |
Offered by | School of Biological Sciences |
Available as a free choice unit? | No |
Overview
Proteins perform a vast array of functions within living organisms. This unit will covering a range of high profile, contemporary topics in Protein Science, from folding and assembly through to dynamics and membrane transport. You will also study how structural studies of macromolecular assemblies are leading to the development of nanodevices.
Pre/co-requisites
Unit title | Unit code | Requirement type | Description |
---|---|---|---|
Proteins | BIOL21111 | Pre-Requisite | Compulsory |
- BIOL21111 Proteins (Compulsory)
Aims
The unit aims to provide students with an introduction to modern Protein Science, covering a representative range of high profile, contemporary topics, from folding and assembly through to dynamics and membrane transport.
Learning outcomes
Knowledge of the way in which proteins fold, assemble, self-polymerise, move and can be observed.
Syllabus
A) Protein folding:
• in vitro: including techniques used to study it. Protein folding landscapes and pathways.
B) Protein dynamics: methods used to study it, including NMR and simulations. Role in protein function.
C) Protein assembly:
• chaperones: proteins which help other proteins to fold
• assembly of multiprotein complexes e.g. viruses, ribosome
D Structures of membrane protein transporters. Sym and Antiporters. ABC transporters. Ion channels.
E) Macromolecular machines and nanobiotechnology. How structural studies of macromolecular assemblies are leading to the development of nanodevices.
Employability skills
- Analytical skills
- Data analysis coursework
- Problem solving
- Data analysis coursework
- Written communication
- Coursework and data analysis problems
Assessment methods
Method | Weight |
---|---|
Other | 20% |
Written exam | 80% |
Feedback methods
- Online discussion.
- Feedback on essay and data handling problems.
Recommended reading
Papers will additionally be recommended by individual lecturers.
Recommended Reading
- Lesk, AM, Introduction to Protein Science Architecture, Function & Genomics (ISBN 987-0-19-954130), Oxford University Press, 2010, Recommended
- Petsko, G & Ringe, D, Protein Structure and Function: Primers in Biology (ISBN 978-1-4051-1922-1), Wiley-Blackwell, 2003, Recommended
- Whitford, D, Proteins: Structure and Function (ISBN: 0-471-49894-7), John Wiley & Sons Ltd, 2005, Recommended
- Williamson, M, How Proteins Work (ISBN: 0815344465), Taylor & Francis 2011, Recommended
Study hours
Scheduled activity hours | |
---|---|
Assessment written exam | 1.3 |
Lectures | 18 |
Independent study hours | |
---|---|
Independent study | 80.7 |
Teaching staff
Staff member | Role |
---|---|
Andrew Doig | Unit coordinator |