Our research

Research involving animals carried out at The University of Manchester requiring a Home Office Licence

At The University of Manchester, our research covers a wide spectrum of diseases in the UK including cardiology, stroke, dementia and cancer.

Overview of diseases

Currently:

• 7.4 million people living with a heart or circulatory disease in the UK (British Heart Foundation)
• 164,901 deaths from cancer between 2015 and 2017 in the UK (Cancer Research UK)
• 850,000 people who have dementia (Alzheimer’s Society)
• More than 100,000 strokes in the UK each year; that is around one stroke every five minutes (Stroke Association)

Overview of animals involved in research

• 59,688 mice
• 18,291 mice (Cancer Research UK Manchester Institute)
• 13,439 zebra fish
• 2668 rats
• 723 xenopus
• 84 sheep
• 97 African-striped mice
• 14 gerbils

Figures represent all research involving animals at The University of Manchester carried out under Home Office Licence for 2020.

• Animal models of fibrotic diseases (PDF, 104KB)
• Biocompatibility of a prototype fully implantable auditory implant microphone (PDF, 82KB)
• Circadian regulation of chronic inflammation (PDF, 103KB)
• Circadian rhythms in health and disease of the musculoskeletal system (PDF, 99KB)
• Genetically altered rodent generation, breeding and maintenance (PDF, 78KB)
• Imaging and radiation treatment of cancer (PDF, 91KB)
• Immune and inflammatory mechanisms in cerebrovascular disease (PDF, 103KB)
• Immune cross-talk between the oral and distant mucosal barriers (PDF, 94KB)
• Neural basis of tactile behaviour (PDF, 72KB)
• New therapeutics for inflammatory bowel conditions (PDF, 98KB)
• Studying cognitive function in animal models of brain disorders (PDF, 94KB)
• The link between diabetes, leaky gut and severity of acute pancreatitis (PDF, 113KB)
• The mechanisms underpinning ‘steroid’ (glucocorticoid) development of obesity and diabetes (PDF, 86KB)
• Treatment of short and long term outcomes of viral lung infection (PDF, 86KB)
• Understanding endogenous protective mechanisms in osteoarthritis; towards a new approach for disease (PDF, 101KB)

• Cellular homeostasis and brain development (PDF, 96KB)
• Circadian regulation of chronic inflammation (PDF, 103kB)
• Genetic analysis of metastatic cancer (PDF, 89KB)
• Immunopathology of experimental blood-stage malaria (PDF, 99KB)
• Investigating how brain immune responses drive behavioural symptoms associated with mild and repeated traumatic brain injury (PDF, 96KB)
• Modelling fibrosis in multiple organs to understand disease (PDF, 92KB)
• Modelling gene therapy for congenital bladder dysfunction (PDF, 94KB)
• Modulating the immune response in cancer (PDF, 89KB)
• New therapeutics for inflammatory bowel conditions (PDF, 98KB)
• Preclinical evaluation of cancer therapeutics (PDF, 100KB)
• Understanding the mechanisms and pathophysiology of heart failure and atrial fibrillation (PDF, 128KB)
• Use of genetically modified biological assemblies to generate improved vaccines (PDF, 96KB)
• Understanding endogenous protective mechanisms in osteoarthritis; towards a new approach for disease management (PDF, 101KB)
• Vascular calcification in kidney dysfunction (PDF, 91KB)

• Assessing novel treatments for endometriosis (PDF, 98KB)
• Circadian regulation of pulmonary immunity (PDF, 103KB) 
• Development and validation of animal models for neurodevelopmental disorders (PDF, 89KB)
• Extracellular matrix mediated control of immune cell recruitment and positioning in health and disease (PDF, 89KB)
• Genes and essential nutrient influences on behaviour (PDF, 96KB)
• Mechanisms of diabetes-associated heart disease (PDF, 70KB)
• Models of tissue injury, regenerative repair, and reconstruction in the limb and appendages (PDF, 88KB)
• Peripheral nerve regeneration (PDF, 82KB)
• Type 2 immunity in infection and maintenance of tissue health (PDF, 96KB)
• Understanding the role of the body clock in behaviour and physiology (PDF, 94KB)
• Generation, breeding and maintenance of genetically altered rodents (PDF, 96KB)
• Understanding vision and developing therapies for blindness (PDF, 96KB)

• A study on treatment and penetrance of inherited cardiac conditions (PDF, 365KB)
• Anorexia and cachexia in aging and disease (PDF, 658KB) 
• Anti-cancer therapy validation (PDF, 541KB)
• Brain networks for memory & executive function in health and disease (PDF, 629KB)
• Brainstem circuits controlling gut-brain communication (PDF, 670KB)
• Cardiac conduction system in health and disease (PDF, 698KB)
• Central regulation of appetite and body weight (PDF, 641KB)
• Control of arousal and autonomic output from the brain (PDF, 647KB)
• Defining immunoregulation during parasitic helminth infection (PDF, 708KB)
• Devices and therapies for cardiovascular interventions and diseases (PDF, 303KB)
• Establishment and healthy maintenance of blood systems (PDF, 346KB)
• Evaluation of developmental and therapeutic potential for human embryos and embryonic stem cells (PDF, 655KB)
• Fish Physiology in an era of climate change (PDF, 657KB)
• How do sinus node disease maintain atrial fibrillation; a mechanistic study of electrical and structural remodelling (PDF, 700KB)
• Immunoregulation during parasitic helminth infection (2019) (PDF, 376KB)
• Inflammation in arterial disease and co-morbidities (PDF, 684KB)
• Inflammatory factors and their effect on memory in Alzheimer’s and aging (PDF, 445KB)
• Mechanisms of breast development and tumorigenesis (PDF, 662KB)
• Novel targets for antiepileptic drug design (PDF, 636KB)
• Radiolabelled molecules for cancer imaging and therapy (PDF, 669KB)
• Regulation miR-29 targets in wound repair (PDF, 361KB)
• Regulation of inflammation in wound repair (2019) (PDF, 666KB)
• Studies of cancer inflammation and immunity in vivo (PDF, 676KB)
• Type 2 inflammation in health and disease (PDF, 653KB)
• Zebrafish models for investigating cancer formation and progression, immune responses and immunotherapy (PDF, 650KB)

• Dysregulation of Skin Homeostasis (PDF, 110KB)
• Identifying New Therapies to Prevent Internal Scarring (PDF, 231KB)
• New Therapeutic Approaches for Inflammatory Joint Disorders (PDF, 128KB)
• Regulation of Glomerular Barrier Function in Health & Disease (PDF, 222KB)
• The Role & Regulation of Reactive Oxygen Species in Development & Regeneration (PDF, 245KB)
• Understanding the Role of Inflammation in Dementia (PDF, 186KB)
• Zebrafish Models of Haemorrhagic Stroke (PDF, 104KB)
• Designing Therapeutic & Diagnostic Nanotechnologies for Medicine (PDF, 2.2MB)
• Determining Important Regulatory Pathways that Control Immune Responses to Infection (2018) (PDF, 142KB)
• Drug Discovery for Parasitic Helminths (PDF, 155KB)

• Advanced Education in Pharmacology (PDF, 200KB)
• Gene Function in Cardiovascular Disease (PDF, 139KB)
• Glucocorticoids and stress in the development of diabetes and obesity (PDF, 272KB)
• New Therapeutic Approaches for Inflammatory Disorders (PDF, 220KB)
• Regulation of glomerular barrier function in health and disease (PDF, 266KB) 
• Evaluation of cognitive function in animal models (PDF, 267KB)
• Postnatal light effects on circadian function (PDF, 106KB)
• Understanding inflammasome dependent inflammation (PDF, 190KB)
• Neural basis of tactile behaviour (PDF, 149KB)
• Cell therapy for diseases of striated muscle (PDF, 151KB)
• Maintenance of barrier immunity in health and disease (PDF, 386KB) 
• The role of inflammation in cerebrovascular disease (PDF, 429KB)
• Understanding inflammation in dementia (PDF, 183KB)
• Determining Important Regulatory Pathways that Control Immune Responses to Infection (2017) (PDF, 427KB)
• Immunogenicity of biologics (PDF, 371KB)
• Maternal fasting and offspring health (PDF, 221KB)
• Treatment and Pathology of Neurological Diseases (PDF, 197KB)

• Modulating inflammation in the GI tract (PDF, 68KB)
• Circadian mechanisms underlying organ rejection (PDF, 193KB)
• PKCα and vascular calcification in kidney dysfunction (PDF, 181KB)
• Skin homeostasis and wound healing (PDF, 376KB)
• Regenerative medicine therapy for renal injury (PDF, 179KB)
• Zebrafish: Development, physiology and disease modelling (PCF, 105KB)
• Modelling therapies for renal malformations (PDF, 191KB)
• Extracellular matrix in development and disease (PDF, 85KB)
• Immunopathology of experimental malaria infection (PDF, 179KB)
• Understanding mechanisms of fibrosis (PDF, 211KB)
• Preclinical evaluation of cancer therapeutics (PDF, 68KB)
• Understanding vision developing therapies (PDF 50KB)
• Development of new models of FTLD-MND (PDF, 81KB)
• Genetic analysis of tumour development (2016) (PDF, 68KB)
• Healing mechanisms of thermal injury wounds (PDF, 45KB)
• Pathophysiology of heart failure (PDF, 52KB)
• Type 2 immunity in infection and tissue homeostasis (PDF, 50KB)
• Circadian Regulation of Processes Underlying Chronic Inflammation (PDF, 117KB)

• Precursor cell therapies for kidney disease (PDF, 84KB)
• Genetic analysis of tumour development (2015) (PDF, 81KB)
• NKT cells and related immunity in health and disease (PDF, 89KB)
• Models of tissue repair, reconstruction and regeneration of the limb (PDF, 46KB)
• Circadian control of behaviour and metabolism (PDF, 47KB)
• Proteolytic cleavage of the LDL receptor (PDF, 62KB)
• The contribution of mast cells and their mediators in inflammatory skin diseases (PDF, 48KB)
• Inflammation and arterial disease (PDF, 48KB)

• Animal models of neurodevelopment disorders (PDF, 53KB)
• Blood flow and tissue oxygenation in rodents (PDF, 50KB)
• Designing a localised drug delivery system to treat endometriosis (PDF, 60KB)
• Novel vitrectomy cutter project: Phase II animal surgery study (PDF, 44KB)
• Pregnancy complications: targeted interventions (PDF, 64KB)
• The long-term effects of prenatal hypoxia on cardiomyocyte function (PDF, 58KB)
• Microenvironment signalling in cancer (PDF, 46KB)
• The role of copper in diabetes and ageing (PDF, 50KB)
• Cancer biology including host immunity in Zebra Fish (PDF, 45KB)
• Development and refinement of Small Animal imaging (PDF, 54KB)
• Immunoregulation during parasitic helminth infection (2014) (PDF, 47KB)
• Regulation of inflammation in wound repair (2014) (PDF, 59KB)
• Regulation of pituitary physiology (PDF, 42KB)