The vast majority of our research involving animals uses mice and rats. Here we detail the precise numbers and types of animal experiments carried out by the University, and on which types of animals.
The graphic below shows the numbers of procedures carried out by the University every year and on what species. The majority of our research involving animals is on mice and rats. The chart below explains the degree of suffering the animals experience, by showing the levels of severity of each procedure.
The term procedure refers to any act that can cause an animal pain, suffering or distress. A procedure can be as mild as an injection or as severe as a surgical intervention where mortality can in rare cases occur. All experiments involve procedures but not all procedures are experiments.
- The law defines the levels of severity animals experience as:
- Subthreshold: where the animals do not suffer from an intervention.
- Mild: causes short-term mild pain, suffering or distress.
- Moderate: causes short-term moderate pain, suffering or distress or long-lasting mild pain, suffering or distress.
- Severe: animals are likely to experience severe pain, suffering or distress, or long-lasting moderate pain, suffering or distress
- Non recovery. The animal is placed under general anaesthetic before the start of the procedure, and is humanely killed without ever regaining consciousness.
Most research involving animals at The University of Manchester is either mild or subthreshold.
We publish here all non-technical summaries of current licenses granted to University of Manchester researchers granted under the Animals (Scientific Procedures) Act 1986.
- Dysregulation of Skin Homeostasis (PDF, 110KB)
- Identifying New Therapies to Prevent Internal Scarring (PDF, 231KB)
- New Therapeutic Approaches for Inflammatory Joint Disorders (PDF, 128KB)
- Regulation of Glomerular Barrier Function in Health & Disease (PDF, 222KB)
- The Role & Regulation of Reactive Oxygen Species in Development & Regeneration (PDF, 245KB)
- Understanding the Role of Inflammation in Dementia (PDF, 186KB)
- Zebrafish Models of Haemorrhagic Stroke (PDF, 104KB)
- Designing Therapeutic & Diagnostic Nanotechnologies for Medicine (PDF, 2.2MB)
- Determining Important Regulatory Pathways that Control Immune Responses to Infection (PDF, 142KB)
- Drug Discovery for Parasitic Helminths (PDF, 155KB)
- Advanced Education in Pharmacology (PDF, 200KB)
- Gene Function in Cardiovascular Disease (PDF, 139KB)
- Glucocorticoids and stress in the development of diabetes and obesity (PDF, 272KB)
- New Therapeutic Approaches for Inflammatory Disorders (PDF, 220KB)
- Regulation of glomerular barrier function in health and disease (PDF, 266KB)
- Evaluation of cognitive function in animal models (PDF, 267KB)
- Postnatal light effects on circadian function (PDF, 106KB)
- Understanding inflammasome dependent inflammation (PDF, 190KB)
- Neural basis of tactile behaviour (PDF, 149KB)
- Cell therapy for diseases of striated muscle (PDF, 151KB)
- Maintenance of barrier immunity in health and disease (PDF, 386KB)
- The role of inflammation in cerebrovascular disease (PDF, 429KB)
- Understanding inflammation in dementia (PDF, 183KB)
- Determining Important Regulatory Pathways that Control Immune Responses to Infection (PDF, 427KB)
- Immunogenicity of biologics (PDF, 371KB)
- Maternal fasting and offspring health (PDF, 221KB)
- Treatment and Pathology of Neurological Diseases (PDF, 197KB)
- Modulating inflammation in the GI tract (PDF, 68KB)
- Circadian mechanisms underlying organ rejection (PDF, 193KB)
- PKCα and vascular calcification in kidney dysfunction (PDF, 181KB)
- Skin homeostasis and wound healing (PDF, 376KB)
- Regenerative medicine therapy for renal injury (PDF, 179KB)
- Zebrafish: Development, physiology and disease modelling (PCF, 105KB)
- Modelling therapies for renal malformations (PDF, 191KB)
- Extracellular matrix in development and disease (PDF, 85KB)
- Immunopathology of experimental malaria infection (PDF, 179KB)
- Understanding mechanisms of fibrosis (PDF, 211KB)
- Preclinical evaluation of cancer therapeutics (PDF, 68KB)
- Understanding vision developing therapies (PDF 50KB)
- Development of new models of FTLD-MND (PDF, 81KB)
- Genetic analysis of tumour development (PDF, 68KB)
- Healing mechanisms of thermal injury wounds (PDF, 45KB)
- Pathophysiology of heart failure (PDF, 52KB)
- Type 2 immunity in infection and tissue homeostasis (PDF, 50KB)
- Circadian Regulation of Processes Underlying Chronic Inflammation (PDF, 117KB)
- Precursor cell therapies for kidney disease (PDF, 84KB)
- Genetic analysis of tumour development (PDF, 81KB)
- NKT cells and related immunity in health and disease (PDF, 89KB)
- Models of tissue repair, reconstruction and regeneration of the limb (PDF, 46KB)
- Circadian control of behaviour and metabolism (PDF, 47KB)
- Proteolytic cleavage of the LDL receptor (PDF, 62KB)
- The contribution of mast cells and their mediators in inflammatory skin diseases (PDF, 48KB)
- Inflammation and arterial disease (PDF, 48KB)
- Animal models of neurodevelopment disorders (PDF, 53KB)
- Blood flow and tissue oxygenation in rodents (PDF, 50KB)
- Designing a localised drug delivery system to treat endometriosis (PDF, 60KB)
- Novel vitrectomy cutter project: Phase II animal surgery study (PDF, 44KB)
- Pregnancy complications: targeted interventions (PDF, 64KB)
- The long-term effects of prenatal hypoxia on cardiomyocyte function (PDF, 58KB)
- Microenvironment signalling in cancer (PDF, 46KB)
- The role of copper in diabetes and ageing (PDF, 50KB)
- Cancer biology including host immunity in Zebra Fish (PDF, 45KB)
- Development and refinement of Small Animal imaging (PDF, 54KB)
- Immunoregulation during parasitic helminth infection (PDF, 47KB)
- Regulation of inflammation in wound repair (PDF, 59KB)
- Regulation of pituitary physiology (PDF, 42KB)
Find out about our research involving animals in previous years on our data archive page.