MSc Precision Medicine / Course details
Year of entry: 2023
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Our Master of Science (MSc) in Precision Medicine will provide training in the principles of precision and stratified medicine and the clinical impact of individual molecular and lifestyle variability.
Precision Medicine is a rapidly changing and exciting area of healthcare. Our understanding of the molecular basis of disease, drug mechanisms and precision medicine has improved dramatically in recent years. Precision or stratified medicine transforms healthcare from a one size fits all approach to a more tailored disease prevention and personalised treatment approach, that takes into account variability in genes, environment, and lifestyle for each person. Currently, there is a distinct shortage of individuals able to translate this knowledge into effective clinical benefit. The aim is to train the next generation of scientists able to fast-track biological and scientific insights into advanced therapies and diagnostic tools.
The MSc provides training in the principles of precision and stratified medicine and the clinical impact of individual molecular and lifestyle variability. In this programme, you will learn about multidisciplinary molecular profiling technologies including genetics, genomics, proteomics and metabolomics and their application to the growing area of precision and stratified medicine. A key benefit of this MSc is the extended 35-week project that can be undertaken at the University, the Manchester Cancer Research Centre or a teaching hospital in Greater Manchester. Our teaching integrates different omic technologies to enable you to undertake precision medicine research.
You can choose from a range of projects that may cover areas such as the use of gene expression profiling, proteomics, metabolomics, stem cell research, tissue culture or pharmacogenetics in the biology of diseases such as cancer, cardiovascular disease, infectious diseases, neurological disease, respiratory disease, stroke or diabetes.
Completing our course may open up a route into PhD research. You may also pursue a career in academia or the pharmaceutical or biotechnology industries, or as a clinical academic.
"Our students undertake ambitious research.
"Projects have explored cancer, cardiovascular disease, inflammation or diabetes, using methods including stem cell research, proteomics, metabolomics, or pharmacogenetics."Janine Lamb / Course Director
Extensive research experience
The 35-week research project for the MSc award offers the chance to conduct ambitious projects in world-leading research groups in areas such as cancer, cardiovascular disease, inflammation, mental health, infectious diseases, stroke or diabetes, using methods such as stem cell research, proteomics, metabolomics, tissue culture or pharmacogenetics.
Omics technologies in precision medicine
You will learn about multidisciplinary molecular profiling technologies including genetics, genomics, proteomics and metabolomics and their application to the growing area of precision and stratified medicine.
Teaching and learning
The taught units are delivered using a variety of face-to-face, workshop and e-learning approaches. There is also an extended 35-week research project for the MSc award. Examples of past research projects include:
- Statins in translational cerebral ischemia: systematic review and meta-analysis of pre-clinical studies;
- Parallel gene expression profiling and histological analysis of tumour tissue microarrays;
- Development of a New Drug For Alzheimer's Disease by Drug Repositioning;
- Identification of genetic variants predisposing to autoimmune idiopathic inflammatory myopathies;
- Effects of differentiating agents on breast cancer stem cells and their sensitivity to DNA-damaging therapies;
- Molecular characterisation of prostate cancer;
- Inhibitors of IAPP Aggregation and Toxicity;
- New Therapies for Type II Diabetes;
- Identifying novel monotherapy and combination therapies for the treatment of Glioma;
- Translation of in vitro to in vivo: investigating the utility of in vitro drug transporter assays to predict inductive effects in the clinic;
- In vivo mechanistic analysis of cancer drug combination therapies;
- Using silk as a biomaterial for nerve regeneration;
- The role of the local tissue environment in immune activation following myocardial damage;
- Identifying genes that drive Breast Cancer to Bone Metastasis;
- High throughput genetic testing in rare disease: applications of personalised medicine;
- Drug resistance and heterogeneity in CML following treatment with imatinib and following perturbation caused by nanoparticle delivery of miRNAs;
- Investigation of a panel of drugs to inhibit the pro-tumourgenic actions of macrophages in breast cancer;
- 3D anatomical reconstruction and molecular mapping of the atrioventricular ring tissues in human embryonic heart and adult rat heart;
- Identification of the genetic basis of disorders associated with the presence of intracranial calcification;
- Species variability in metabolism as a translational factor influencing susceptibility to adverse drug reactions in man.
Find out more about postgraduate teaching and learning at The University of Manchester.
Coursework and assessment
Course unit details
The MSc course consists of four taught units - which together make up the PGCert - plus an extended 35-week project. The four taught units run throughout Semester 1, and are taught using a variety of face-to-face, workshop and e-learning approaches. Further details can be found by clicking on the units in the table below.
The research project for the MSc award begins in Semester 1, then runs throughout Semester 2, and has two main elements, Research Project 1 (10 weeks) and Research Project 2 (25 weeks). Further details can be found by clicking on the units in the table below.
Clinical Masterclass course unit
The Clinical Masterclass course unit is an optional non-credit bearing unit that may be available for intercalated medical students, subject to availability. The unit consists of a series of seminars, workshops and e-learning.
This optional unit contributes to personal and professional development in the experience, knowledge and skills training required for effective clinical practice and success, with a strong emphasis on clinical academic research.
Course unit list
The course unit details given below are subject to change, and are the latest example of the curriculum available on this course of study.
|Research Project 1||BIOL66121||30||Mandatory|
|Research Project 2||BIOL66132||90||Mandatory|
|Genetics, Genetic Epidemiology, Transcriptomics and Functional Genomics||BIOL72021||15||Mandatory|
|Proteomics and Metabolomics||BIOL72031||15||Mandatory|
|Laboratory Skills Unit||MEDN66111||15||Mandatory|
A partnership between the University and local NHS Trusts aims to accelerate advances in healthcare through clinical integration.
Our course also has partnerships with interdisciplinary organisations, for example the Manchester Cancer Research Centre, Stoller Biomarker Discovery Centre, and Manchester Collaborative Centre for Inflammation Research, a collaboration between UK pharmaceutical companies and the University.
What our students say
After finishing my undergraduate studies, I wanted to develop my research skills and gain more knowledge in omic technologies.
The 6 month laboratory project helped me achieve my aims and enhance my skills. The seminars delivered by lecturers who worked in industry also helped me understand difficult topics. It was an amazing opportunity to discover the latest technologies and was great preparation for a PhD and a career in the industry.Ilinca Neacsu / Alumni from course formally called Translational Medicine
The lectures and seminars that we had with lecturers from the pharmaceutical industry was a great chance to understand how research is performed outside of the University and what opportunities exist for researchers in industry. Moreover, the emphasis given on proper preparation and organisation of projects, critically reviewing published bibliographies, and effectively communicating research work through verbal and written channels will develop useful skills for the future. Elpida Tsonou
Really interesting and stimulating course which provides a detailed overview and first-hand experience of how systems medicine can be used to advance human healthcare. Jamie Ellingford
The course was amazing. It helped me to become more confident in working in the lab individually. I learnt so many valuable skills and made some good friends along the way. Nadia Iqbal
The course provided me with knowledge of novel techniques that I can now incorporate into my research. I would recommend the course to anybody. William Critchley
I feel the course has given me excellent preparation for my PhD and would greatly recommend it to anyone looking for a research career. Shaun Wood
Please note the opinions above were provided for the precursor to this course, MRes Translational Medicine.
Our MSc students are based within state-of-the-art academic research facilities, including the Manchester Institute for Biotechnology (MIB) and Michael Smith, Stopford and AV Hill Buildings.
The MIB is equipped with facilities for training in biotechnologies for medical healthcare.
Research projects are carried out within the University, the Manchester Cancer Research Centre or one of the Greater Manchester teaching hospitals.
You will be able to access a range of facilities throughout the University.