MPharm Pharmacy with a Foundation Year

Year of entry: 2022

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Course unit details:
The Medicine (Year 3) - Drug Development Process 2

Course unit fact file
Unit code	PHAR30100
Credit rating	30
Unit level	Level 3
Teaching period(s)	Full year
Offered by	Pharmacy
Available as a free choice unit?	No

Overview

Provide a good understanding of pharmacokinetics of small molecules. Demonstrate application of scientific principles in the development of different drug formulations. Integrate knowledge of disease states, different routes of administration and pharmacokinetics. Develop problem solving and data analysis skills. Work effectively within team and develop communication skills through Pharmacokinetic Simulation and Drug Development workshops.

Pre/co-requisites

Unit title	Unit code	Requirement type	Description
The Medicine (Year 1)	PHAR10100	Pre-Requisite	Compulsory
The Pharmacist (Year 1)	PHAR10200	Pre-Requisite	Compulsory
The Patient (Year 1): Introduction to Human Biology	PHAR10300	Pre-Requisite	Compulsory
The Public (Year 1): Public Health Microbiology	PHAR10400	Pre-Requisite	Compulsory
The Medicine (Year 2)	PHAR20100	Pre-Requisite	Compulsory
The Pharmacist (Year 2): Law and Professional Practice	PHAR20200	Pre-Requisite	Compulsory
The Patient (Year 2): Pathology, Pharmacology & Therapeutics 1	PHAR20300	Pre-Requisite	Compulsory
The Public (Year 2): Infectious Disease & Prophylaxis/Treatment in Public Health	PHAR20400	Pre-Requisite	Compulsory
Integrated Professional Practice (Part 1)	PHAR10500	Pre-Requisite	Compulsory
Yr 2 Integrated Prof Practice	PHAR20500	Pre-Requisite	Compulsory

Aims

Pharmaceutics: To provide an understanding of the biological factors and their variability affecting the design, delivery and quality of medicines. To assess the biopharmaceutics of oral and parenteral medicines in case studies and to integrate into clinical pharmacy tutorials.

Drug Disposition and Pharmacokinetics: To provide an understanding of drug disposition processes and properties of metabolites. To understand metabolic and transporter-mediated drug-drug interactions and consequences on drug efficacy and safety.

To develop core knowledge of pharmacokinetics of a drug following single and multiple dose administration; apply such knowledge to the rational design of dosage regimens in different disease states.

Simulation workshops: To Integrate knowledge and scientific principles outlined above with clinical practice.

Drug Development workshop: Introduction to the concepts of product safety, formulation, strategy, clinical trials, licensing, registration and marketing

Assessment methods

End of semester 1:

2h written exam, Pharmaceutics unit - 30% of the Medicine PHAR30100 mark

End of semester 2:

2h written exam, Drug Disposition and Pharmacokinetics unit - 50% of the Medicine PHAR30100 mark

Drug Development Workshop – 10% (group mark)

Simulation workshops – 10% (group mark)

Assessment	Weighting	Equivalent Credits
Semester 1 exam – Pharmaceutics	30%	9
Semester 2 exam – Drug disposition and pharmacokinetics	50%	15
Combined Simulation and Drug Development Workshops	20%	6

N.B. In order to progress, student needs to pass each individual exam, i.e., Pharmaceutics (sem 1) and Drug Disposition and Pharmacokinetics (sem 2) exams. In addition, combined Drug development and Simulation workshop mark needs to exceed 40%.

Formative assessment: Formative assessments will be done in weeks 4, 9 and 12 in semester 1; all details will be provided on Blackboard. Answers will subsequently be uploaded on Blackboard and/or discussed in interactive feedback/Q&A sessions.

Attendance requirements

Attendance of all PHAR30100 workshops is compulsory for MPharm and BSc students. This applies to Pharmaceutics case studies workshops (sem 1), Simulation workshops (sem 1) and Drug Development Workshops (sem 1 and 2). Attendance is compulsory regardless whether workshops are done in person or online.

Feedback methods

Feedback is given in the weekly online Q&A sessions scheduled for both Pharmaceutics and Drug Disposition components (sem 1) and Pharmacokinetics (sem 2).

Feedback is also given in all the workshops and scheduled Revision sessions (detailed in the unit timetables for sem 1 and sem 2).

Students are encouraged to discuss questions with academic staff and peers in interactive Q&A sessions, Discussion Boards (Pharmaceutics workshops) or to contact academic staff by email.

Contact details:

Aleksandra.Galetin@manchester.ac.uk

(Unit lead; Specific questions related to material covered in Drug disposition & Pharmacokinetics component and Simulation workshops)

Alain.Pluen@manchester.ac.uk and individual staff member associated with a particular Pharmaceutics topic (Pharmaceutics workshops)

Leon.Aarons@manchester.ac.uk (Drug Development workshops)

Study hours

Scheduled activity hours
Assessment written exam	4
Lectures	56
Practical classes & workshops	36

Independent study hours
Independent study	190

Teaching staff

Staff member	Role
Aleksandra Galetin	Unit coordinator

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