- UCAS course code
- UCAS institution code
Year of entry: 2022
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Course unit details:
The Medicine (Year 3) - Drug Development Process 2
|Unit level||Level 3|
|Teaching period(s)||Full year|
|Available as a free choice unit?||No|
Provide a good understanding of pharmacokinetics of small molecules. Demonstrate application of scientific principles in the development of different drug formulations. Integrate knowledge of disease states, different routes of administration and pharmacokinetics. Develop problem solving and data analysis skills. Work effectively within team and develop communication skills through Pharmacokinetic Simulation and Drug Development workshops.
|Unit title||Unit code||Requirement type||Description|
|The Medicine (Year 1)||PHAR10100||Pre-Requisite||Compulsory|
|The Pharmacist (Year 1)||PHAR10200||Pre-Requisite||Compulsory|
|The Patient (Year 1): Introduction to Human Biology||PHAR10300||Pre-Requisite||Compulsory|
|The Public (Year 1): Public Health Microbiology||PHAR10400||Pre-Requisite||Compulsory|
|The Medicine (Year 2)||PHAR20100||Pre-Requisite||Compulsory|
|The Pharmacist (Year 2): Law and Professional Practice||PHAR20200||Pre-Requisite||Compulsory|
|The Patient (Year 2): Pathology, Pharmacology & Therapeutics 1||PHAR20300||Pre-Requisite||Compulsory|
|The Public (Year 2): Infectious Disease & Prophylaxis/Treatment in Public Health||PHAR20400||Pre-Requisite||Compulsory|
|Integrated Professional Practice (Part 1)||PHAR10500||Pre-Requisite||Compulsory|
|Yr 2 Integrated Prof Practice||PHAR20500||Pre-Requisite||Compulsory|
Pharmaceutics: To provide an understanding of the biological factors and their variability affecting the design, delivery and quality of medicines. To assess the biopharmaceutics of oral and parenteral medicines in case studies and to integrate into clinical pharmacy tutorials.
Drug Disposition and Pharmacokinetics: To provide an understanding of drug disposition processes and properties of metabolites. To understand metabolic and transporter-mediated drug-drug interactions and consequences on drug efficacy and safety.
To develop core knowledge of pharmacokinetics of a drug following single and multiple dose administration; apply such knowledge to the rational design of dosage regimens in different disease states.
Simulation workshops: To Integrate knowledge and scientific principles outlined above with clinical practice.
Drug Development workshop: Introduction to the concepts of product safety, formulation, strategy, clinical trials, licensing, registration and marketing
End of semester 1:
2h written exam, Pharmaceutics unit - 30% of the Medicine PHAR30100 mark
End of semester 2:
2h written exam, Drug Disposition and Pharmacokinetics unit - 50% of the Medicine PHAR30100 mark
Drug Development Workshop – 10% (group mark)
Simulation workshops – 10% (group mark)
Semester 1 exam – Pharmaceutics
Semester 2 exam – Drug disposition and pharmacokinetics
Combined Simulation and Drug Development Workshops
N.B. In order to progress, student needs to pass each individual exam, i.e., Pharmaceutics (sem 1) and Drug Disposition and Pharmacokinetics (sem 2) exams. In addition, combined Drug development and Simulation workshop mark needs to exceed 40%.
Formative assessment: Formative assessments will be done in weeks 4, 9 and 12 in semester 1; all details will be provided on Blackboard. Answers will subsequently be uploaded on Blackboard and/or discussed in interactive feedback/Q&A sessions.
Attendance of all PHAR30100 workshops is compulsory for MPharm and BSc students. This applies to Pharmaceutics case studies workshops (sem 1), Simulation workshops (sem 1) and Drug Development Workshops (sem 1 and 2). Attendance is compulsory regardless whether workshops are done in person or online.
Feedback is given in the weekly online Q&A sessions scheduled for both Pharmaceutics and Drug Disposition components (sem 1) and Pharmacokinetics (sem 2).
Feedback is also given in all the workshops and scheduled Revision sessions (detailed in the unit timetables for sem 1 and sem 2).
Students are encouraged to discuss questions with academic staff and peers in interactive Q&A sessions, Discussion Boards (Pharmaceutics workshops) or to contact academic staff by email.
(Unit lead; Specific questions related to material covered in Drug disposition & Pharmacokinetics component and Simulation workshops)
Alain.Pluen@manchester.ac.uk and individual staff member associated with a particular Pharmaceutics topic (Pharmaceutics workshops)
Leon.Aarons@manchester.ac.uk (Drug Development workshops)
Pharmaceutics (2nd edition) Aulton (ed.), Churchill Livingstone (2002)
Principles of Human Physiology (any edition) Germann & Stanfield
Clinical Pharmacokinetics: concepts and applications. Rowland M and Tozer T. 4th edition. Philadelphia, London: Lippincott Williams & Wilkins, 2010
|Scheduled activity hours|
|Assessment written exam||4|
|Practical classes & workshops||36|
|Independent study hours|
|Aleksandra Galetin||Unit coordinator|